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Beta TRCP (BTRC) (NM_003939) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214799L4V
- LentiORF®
-
Lenti ORF particles, BTRC (mGFP-tagged)-Human beta-transducin repeat containing (BTRC), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,590.00
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CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | Beta TRCP (BTRC) (NM_003939) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_003939 |
| ORF Size | 1707 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214799).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_003939.2 |
| RefSeq Size | 6038 bp |
| RefSeq ORF | 1710 bp |
| Locus ID | 8945 |
| Domains | WD40, F-box |
| Protein Families | Druggable Genome |
| Protein Pathways | Hedgehog signaling pathway, Oocyte meiosis, Ubiquitin mediated proteolysis, Wnt signaling pathway |
| MW | 64.9 kDa |
| Gene Summary | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] |
Documents
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| SDS |
