DROSHA (NM_013235) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC213916L3V
- LentiORF®
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Lenti ORF particles, DROSHA (Myc-DDK tagged) - Human drosha, ribonuclease type III (DROSHA), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 21,660.00
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Specifications
Product Data | |
Product Name | DROSHA (NM_013235) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_013235 |
ORF Size | 4122 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC213916).
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OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_013235.2 |
RefSeq Size | 4764 bp |
RefSeq ORF | 4125 bp |
Locus ID | 29102 |
Domains | RIBOc, DSRM |
MW | 159.1 kDa |
Gene Summary | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] |
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