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CA8 (NM_004056) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC210228L1V
- LentiORF®
-
Lenti ORF particles, CA8 (Myc-DDK tagged) - Human carbonic anhydrase VIII (CA8), 200ul, >10^7 TU/mL
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CNY 8,170.00
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Specifications
| Product Data | |
| Product Name | CA8 (NM_004056) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CA-RP; CA-VIII; CALS; CAMRQ3; CARP |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_004056 |
| ORF Size | 870 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC210228).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004056.4 |
| RefSeq Size | 2278 bp |
| RefSeq ORF | 873 bp |
| Locus ID | 767 |
| Domains | carb_anhydrase |
| Protein Families | Druggable Genome |
| Protein Pathways | Nitrogen metabolism |
| MW | 33 kDa |
| Gene Summary | The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
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