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CIAO1 (NM_004804) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC207586L3V
- LentiORF®
-
Lenti ORF particles, CIAO1 (Myc-DDK tagged) - Human cytosolic iron-sulfur protein assembly 1 (CIAO1), 200ul, >10^7 TU/mL
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CNY 8,930.00
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规格
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Specifications
| Product Data | |
| Product Name | CIAO1 (NM_004804) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CIA1; WDR39 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_004804 |
| ORF Size | 1017 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC207586).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004804.2 |
| RefSeq Size | 4053 bp |
| RefSeq ORF | 1020 bp |
| Locus ID | 9391 |
| Domains | WD40 |
| Protein Families | Transcription Factors |
| MW | 37.8 kDa |
| Gene Summary | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).[UniProtKB/Swiss-Prot Function] |
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