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FAM175B (ABRAXAS2) (NM_032182) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC203856L3V
- LentiORF®
-
Lenti ORF particles, FAM175B (Myc-DDK tagged) - Human family with sequence similarity 175, member B (FAM175B), 200ul, >10^7 TU/mL
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CNY 8,550.00
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Specifications
| Product Data | |
| Product Name | FAM175B (ABRAXAS2) (NM_032182) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ABRO1; FAM175B; KIAA0157 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_032182 |
| ORF Size | 933 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC203856).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_032182.3, NP_115558.2 |
| RefSeq Size | 3008 bp |
| RefSeq ORF | 1248 bp |
| Locus ID | 23172 |
| MW | 34.8 kDa |
| Gene Summary | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).[UniProtKB/Swiss-Prot Function] |
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