United States
Germany
Japan
United Kingdom
China
FKBP52 (FKBP4) (NM_002014) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC200713L1V
- LentiORF®
-
Lenti ORF particles, FKBP4 (Myc-DDK tagged) - Human FK506 binding protein 4, 59kDa (FKBP4), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | FKBP52 (FKBP4) (NM_002014) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_002014 |
| ORF Size | 1377 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200713).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_002014.2 |
| RefSeq Size | 3757 bp |
| RefSeq ORF | 1380 bp |
| Locus ID | 2288 |
| Domains | FKBP, TPR |
| Protein Families | Druggable Genome |
| MW | 51.8 kDa |
| Gene Summary | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
