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Olr1 (NM_138648) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226641L4V
- LentiORF®
-
Lenti ORF particles, Olr1 (GFP-tagged) - Mouse oxidized low density lipoprotein (lectin-like) receptor 1 (Olr1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Olr1 (NM_138648) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | LOX-1; Scare1; SR-EI |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_138648 |
| ORF Size | 1089 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226641).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_138648.2, NP_619589.2 |
| RefSeq Size | 3581 bp |
| RefSeq ORF | 1092 bp |
| Locus ID | 108078 |
| Gene Summary | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).[UniProtKB/Swiss-Prot Function] |
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