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Usp36 (NM_001033528) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226452L3V
- LentiORF®
-
Lenti ORF particles, Usp36 (Myc-DDK-tagged) - Mouse ubiquitin specific peptidase 36 (Usp36), 200ul, >10^7 TU/mL
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CNY 16,340.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Usp36 (NM_001033528) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2700002L06Rik; mKIAA1453 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001033528 |
| ORF Size | 3294 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226452).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001033528.1, NP_001028700.1 |
| RefSeq Size | 5609 bp |
| RefSeq ORF | 3297 bp |
| Locus ID | 72344 |
| Gene Summary | Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Proteasome Activity Influences UV-Mediated Subnuclear Localization Changes of NPM
,null,
PLoS ONE
,PubMed ID 23554979
[Usp36]
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