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Krit1 (NM_001170552) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226178L4V
- LentiORF®
-
Lenti ORF particles, Krit1 (GFP-tagged) - Mouse KRIT1, ankyrin repeat containing (Krit1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 13,110.00
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Specifications
| Product Data | |
| Product Name | Krit1 (NM_001170552) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2010007K12Rik; A630036P20Rik; AA432855; AI450393; AI643869; BB155247; BB235701; Ccm1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001170552 |
| ORF Size | 2091 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226178).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001170552.1, NP_001164023.1 |
| RefSeq Size | 6034 bp |
| RefSeq ORF | 2094 bp |
| Locus ID | 79264 |
| Gene Summary | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity). Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.[UniProtKB/Swiss-Prot Function] |
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