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Map3k8 (NM_007746) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224251L3V
- LentiORF®
-
Lenti ORF particles, Map3k8 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8), 200ul, >10^7 TU/mL
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CNY 9,120.00
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Specifications
| Product Data | |
| Product Name | Map3k8 (NM_007746) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_007746 |
| ORF Size | 1401 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224251).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007746.2, NP_031772.1 |
| RefSeq Size | 2507 bp |
| RefSeq ORF | 1404 bp |
| Locus ID | 26410 |
| Gene Summary | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.[UniProtKB/Swiss-Prot Function] |
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