United States
Germany
Japan
United Kingdom
China
Map3k8 (NM_007746) Mouse Untagged Clone
CAT＃: MC216294
Map3k8 (untagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8), (10ug)
CNY 6,080.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC216294 representing NM_007746
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGTACATGAGCACTGGAAGTGACGAGAAAGAAGAAATTGATTTATTAATTAAGCATTTAAACGTGT CAGAAGTCATAGACATAATGGAGAACCTTTATGCAAGTGAAGAGCCAGGAGTGTATGAGCCCAGTCTGAT GACCATGTATCCAGACAGCAATCAAAATGAGGAACGTTCGGAGTCACTGCTTCGGAGTGGCCAGGAGGTT CCCTGGCTGTCATCTGTCAGATATGGGACCGTGGAGGATCTGCTTGCATTTGCAAACCATGTCTCCAATA TGACAAAGCATTTTTATGGACGTCGACCACAAGAATGTGGAATTTTATTAAATATGGTAATCAGTCCCCA GAATGGCCGCTACCAAATCGATTCGGATGTTCTCCTTGTTCCTTGGAAGCTGACATACAGGAACATCGGC TCTGGTTTCGTTCCTCGGGGGGCCTTTGGAAAAGTATACTTAGCCCAAGACATGAAGACAAAGAAAAGAA TGGCGTGCAAACTGATCCCTATAGATCAGTTTAAGCCATCGGATGTGGAAATCCAGGCCTGTTTCCGGCA TGAGAACATTGCTGAGTTATATGGTGCCGTCCTATGGGGCGATACTGTCCATCTCTTTATGGAAGCCGGC GAGGGAGGGTCTGTTCTGGAGAAACTGGAGAGTTGTGGGCCCATGAGAGAATTTGAAATTATTTGGGTGA CGAAGCACATTCTCAAGGGACTTGATTTTCTGCACTCCAAGAAAGTGATCCACCATGATATTAAACCTAG CAACATTGTATTCATGTCTACAAAAGCTGTTTTGGTAGATTTTGGCCTGAGTGTTAAGATGACTGAAGAT GTCTATCTTCCCAAGGACCTCCGGGGAACAGAGATATACATGAGCCCAGAGGTGATCCTATGTCGGGGCC ATTCCACAAAAGCCGACATCTACAGCCTTGGAGCCACACTCATCCACATGCAGACAGGCACCCCACCCTG GGTGAAGCGCTACCCTCGATCAGCCTATCCCTCCTACCTATACATTATCCACAAGCAGGCACCTCCCCTG GAAGACATCGCTGGTGACTGCAGTCCAGGCATGAGGGAGCTGATAGAAGCTGCCCTGGAGAGGAACCCCA ACCACCGCCCCAAAGCAGCAGACCTACTGAAACATGAAGCCCTGAATCCCCCAAGAGAGGACCAGCCACG ATGTCAGAGTCTGGACTCTGCCCTCTTTGAACGGAAGAGGCTGCTGAGCAGGAAGGAACTACAACTTCCT GAGAACATTGCTGATTCATCATGCACAGGCAGCACCGAAGAGTCTGAAGTGCTCAGGAGACAGCGTTCCC TCTACATTGACCTCGGAGCTCTGGCTGGCTACTTCAATATTGTTCGTGGGCCACCAACCCTGGAATACGG CTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_007746 |
| Insert Size | 1404 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_007746.2, NP_031772.1 |
| RefSeq Size | 2507 bp |
| RefSeq ORF | 1404 bp |
| Locus ID | 26410 |
| UniProt ID | Q07174 |
| Gene Summary | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG224251 | Map3k8 (tGFP-tagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8), (10ug) |
CNY 4,470.00 |
|
| MR224251 | Map3k8 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8) |
CNY 3,656.00 |
|
| MR224251L3 | Lenti ORF clone of Map3k8 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8) |
CNY 5,990.00 |
|
| MR224251L4 | Lenti ORF clone of Map3k8 (mGFP-tagged) - Mouse mitogen-activated protein kinase kinase kinase 8 (Map3k8) |
CNY 5,990.00 |
