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Ect2 (NM_007900) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223423L3V
- LentiORF®
-
Lenti ORF particles, Ect2 (Myc-DDK-tagged) - Mouse ect2 oncogene (Ect2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 14,250.00
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Specifications
| Product Data | |
| Product Name | Ect2 (NM_007900) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI528536; mKIAA4037 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_007900 |
| ORF Size | 2739 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223423).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007900.3, NP_031926.2 |
| RefSeq Size | 4095 bp |
| RefSeq ORF | 2742 bp |
| Locus ID | 13605 |
| Gene Summary | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.[UniProtKB/Swiss-Prot Function] |
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