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Amer1 (NM_175179) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222769L3V
- LentiORF®
-
Lenti ORF particles, Amer1 (Myc-DDK-tagged) - Mouse family with sequence similarity 123, member B (Fam123b), 200ul, >10^7 TU/mL
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CNY 16,720.00
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Specifications
| Product Data | |
| Product Name | Amer1 (NM_175179) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2810002O09Rik; AW492303; Fam123b; Wtx |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_175179 |
| ORF Size | 3396 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222769).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_175179.4, NP_780388.2 |
| RefSeq Size | 8476 bp |
| RefSeq ORF | 3399 bp |
| Locus ID | 72345 |
| Gene Summary | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development (By similarity).[UniProtKB/Swiss-Prot Function] |
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