Nlrp12 (NM_001033431) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR221409L4V
- LentiORF®
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Lenti ORF particles, Nlrp12 (GFP-tagged) - Mouse NLR family, pyrin domain containing 12 (Nlrp12), 200ul, >10^7 TU/mL
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CNY 17,575.00
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Specifications
Product Data | |
Product Name | Nlrp12 (NM_001033431) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Nalp12; PYPAF7 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_001033431 |
ORF Size | 3162 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR221409).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001033431.1, NP_001028603.1 |
RefSeq Size | 4329 bp |
RefSeq ORF | 3165 bp |
Locus ID | 378425 |
Gene Summary | Plays an essential role as an potent mitigator of inflammation (PubMed:26521018, PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:30559449). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (PubMed:30212649).[UniProtKB/Swiss-Prot Function] |
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