Topbp1 (NM_176979) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR212017L4V
- LentiORF®
Lenti ORF particles, Topbp1 (GFP-tagged) - Mouse topoisomerase (DNA) II binding protein 1 (Topbp1), 200ul, >10^7 TU/mL
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CNY 23,370.00
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Specifications
Product Data | |
Product Name | Topbp1 (NM_176979) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; mKIAA0259 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_176979 |
ORF Size | 4545 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR212017).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_176979.5, NP_795953.2 |
RefSeq Size | 5112 bp |
RefSeq ORF | 4548 bp |
Locus ID | 235559 |
Gene Summary | Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity).[UniProtKB/Swiss-Prot Function] |
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