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Ptprs (BC052462) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR212012L4V
- LentiORF®
-
Lenti ORF particles, Ptprs (GFP-tagged) - Mouse protein tyrosine phosphatase, receptor type, S (cDNA clone MGC:63375 IMAGE:6834684), 200ul, >10^7 TU/mL
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CNY 23,180.00
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Specifications
| Product Data | |
| Product Name | Ptprs (BC052462) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | PTP-NU3, PTPsigma |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC052462 |
| ORF Size | 4503 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR212012).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC052462.1 |
| RefSeq Size | 5588 bp |
| RefSeq ORF | 4505 bp |
| Locus ID | 19280 |
| Gene Summary | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).[UniProtKB/Swiss-Prot Function] |
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