Tsc1 (BC052399) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR211709L4V

  • LentiORF®

Lenti ORF particles, Tsc1 (GFP-tagged) - Mouse tuberous sclerosis 1 (cDNA clone MGC:63425 IMAGE:5720967), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 16,910.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Tsc1 (BC052399) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms hamartin
Vector pLenti-C-mGFP-P2A-Puro
ACCN BC052399
ORF Size 3444 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR211709).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC052399.1
RefSeq Size 4829 bp
RefSeq ORF 3446 bp
Locus ID 64930
Gene Summary In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (PubMed:16707451). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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