Pink1 (NM_026880) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR209092L2V
- LentiORF®
Lenti ORF particles, Pink1 (GFP-tagged) - Mouse PTEN induced putative kinase 1 (Pink1), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 11,685.00
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Specifications
Product Data | |
Product Name | Pink1 (NM_026880) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | 1190006F07Rik; AU042772; AW557854; BRPK; mFLJ00387 |
Vector | pLenti-C-mGFP |
ACCN | NM_026880 |
ORF Size | 1740 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR209092).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_026880.2, NP_081156.2 |
RefSeq Size | 2367 bp |
RefSeq ORF | 1743 bp |
Locus ID | 68943 |
Gene Summary | Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins (PubMed:24652937). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:24784582). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (By similarity). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24784582). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (PubMed:24652937).[UniProtKB/Swiss-Prot Function] |
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