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Smad4 (NM_008540) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208755L3V
- LentiORF®
-
Lenti ORF particles, Smad4 (Myc-DDK-tagged) - Mouse MAD homolog 4 (Drosophila) (Smad4), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 10,070.00
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Specifications
| Product Data | |
| Product Name | Smad4 (NM_008540) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW743858; D18Wsu70e; DPC4; Madh4 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008540 |
| ORF Size | 1656 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208755).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008540.2 |
| RefSeq Size | 3361 bp |
| RefSeq ORF | 1656 bp |
| Locus ID | 17128 |
| Gene Summary | Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.[UniProtKB/Swiss-Prot Function] |
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