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Blnk (NM_008528) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207297L4V
- LentiORF®
-
Lenti ORF particles, Blnk (GFP-tagged) - Mouse B-cell linker (Blnk), 200ul, >10^7 TU/mL
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CNY 10,070.00
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Specifications
| Product Data | |
| Product Name | Blnk (NM_008528) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_008528 |
| ORF Size | 1371 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207297).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008528.4 |
| RefSeq Size | 2097 bp |
| RefSeq ORF | 1374 bp |
| Locus ID | 17060 |
| Gene Summary | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.[UniProtKB/Swiss-Prot Function] |
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