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Serpina5 (NM_172953) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206361L3V
- LentiORF®
-
Lenti ORF particles, Serpina5 (Myc-DDK-tagged) - Mouse serine (or cysteine) peptidase inhibitor, clade A, member 5 (Serpina5), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Serpina5 (NM_172953) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4933415L04; PAI-3; Pci |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_172953 |
| ORF Size | 1218 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206361).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172953.1, NP_766541.1, NP_766541.2 |
| RefSeq Size | 2162 bp |
| RefSeq ORF | 1218 bp |
| Locus ID | 268591 |
| Gene Summary | Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity).[UniProtKB/Swiss-Prot Function] |
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