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Sqstm1 (BC006019) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206359L4V
- LentiORF®
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Lenti ORF particles, Sqstm1 (GFP-tagged) - Mouse sequestosome 1 (cDNA clone MGC:5968 IMAGE:3487289), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 11,115.00
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Specifications
| Product Data | |
| Product Name | Sqstm1 (BC006019) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | A170, STAP, OSF-6, p62 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC006019 |
| ORF Size | 1212 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206359).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC006019, AAH06019 |
| RefSeq Size | 2013 bp |
| RefSeq ORF | 1214 bp |
| Locus ID | 18412 |
| Gene Summary | Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Promotes relocalization of 'Lys-63'-linked ubiquitinated TMEM173/STING to autophagosomes (By similarity).[UniProtKB/Swiss-Prot Function] |
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