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Pofut1 (NM_080463) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206140L4V
- LentiORF®
-
Lenti ORF particles, Pofut1 (GFP-tagged) - Mouse protein O-fucosyltransferase 1 (Pofut1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Pofut1 (NM_080463) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | mKIAA0180; O-FucT-1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_080463 |
| ORF Size | 1182 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206140).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_080463.3, NP_536711.3 |
| RefSeq Size | 5618 bp |
| RefSeq ORF | 1182 bp |
| Locus ID | 140484 |
| Gene Summary | Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).[UniProtKB/Swiss-Prot Function] |
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