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Maea (BC039054) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206018L3V
- LentiORF®
-
Lenti ORF particles, Maea (Myc-DDK-tagged) - Mouse macrophage erythroblast attacher (cDNA clone MGC:6504 IMAGE:2648667), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Maea (BC039054) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1110030D19Rik; EMP; Gid9 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC039054 |
| ORF Size | 1155 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206018).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC039054.1 |
| RefSeq Size | 2128 bp |
| RefSeq ORF | 1157 bp |
| Locus ID | 59003 |
| Gene Summary | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (PubMed:16707498). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis (PubMed:16707498, PubMed:17071116). Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (PubMed:16707498). May contribute to nuclear architecture and cells division events (By similarity).[UniProtKB/Swiss-Prot Function] |
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