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Apbb1 (BC048395) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206000L3V
- LentiORF®
-
Lenti ORF particles, Apbb1 (Myc-DDK-tagged) - Mouse amyloid beta (A4) precursor protein-binding, family B, member 1 (cDNA clone MGC:56969 IMAGE:6392016), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Apbb1 (BC048395) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Fe65; Rir |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC048395 |
| ORF Size | 1152 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206000).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC048395, AAH48395 |
| RefSeq Size | 2065 bp |
| RefSeq ORF | 1154 bp |
| Locus ID | 11785 |
| Gene Summary | Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).[UniProtKB/Swiss-Prot Function] |
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