Otub1 (NM_134150) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR203606L1V
- LentiORF®
-
Lenti ORF particles, Otub1 (Myc-DDK-tagged) - Mouse OTU domain, ubiquitin aldehyde binding 1 (Otub1), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
Product Data | |
Product Name | Otub1 (NM_134150) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | AI850305 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_134150 |
ORF Size | 816 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR203606).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_134150.2, NP_598911.1 |
RefSeq Size | 1677 bp |
RefSeq ORF | 816 bp |
Locus ID | 107260 |
Gene Summary | Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.[UniProtKB/Swiss-Prot Function] |
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