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Cdc34 (NM_177613) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR202861L3V
- LentiORF®
-
Lenti ORF particles, Cdc34 (Myc-DDK-tagged) - Mouse cell division cycle 34 homolog (S. cerevisiae) (Cdc34), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Cdc34 (NM_177613) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI327276; E2-CDC34; UBE2R1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_177613 |
| ORF Size | 708 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR202861).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_177613.2, NP_808281.1 |
| RefSeq Size | 1295 bp |
| RefSeq ORF | 708 bp |
| Locus ID | 216150 |
| Gene Summary | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin.[UniProtKB/Swiss-Prot Function] |
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