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Kctd11 (NM_153143) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR202806L3V
- LentiORF®
-
Lenti ORF particles, Kctd11 (Myc-DDK-tagged) - Mouse potassium channel tetramerisation domain containing 11 (Kctd11), 200ul, >10^7 TU/mL
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CNY 7,410.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Kctd11 (NM_153143) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AF465352; Ren |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_153143 |
| ORF Size | 696 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR202806).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_153143.4, NP_694783.1 |
| RefSeq Size | 2740 bp |
| RefSeq ORF | 699 bp |
| Locus ID | 216858 |
| Gene Summary | Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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KCTD11 inhibits progression of lung cancer by binding to β‐catenin to regulate the activity of the Wnt and Hippo pathways. KCTD11 inhibits progression of lung cancer by binding to β‐catenin to regulate the activity of the Wnt and Hippo pathways
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 34453479
[Kctd11]
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