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Snca (NM_001042451) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR200876L4V
- LentiORF®
-
Lenti ORF particles, Snca (GFP-tagged) - Mouse synuclein, alpha (Snca), transcript variant 1, 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Snca (NM_001042451) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | alpha-Syn; alphaSYN; NACP |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001042451 |
| ORF Size | 420 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR200876).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001042451.1 |
| RefSeq Size | 1296 bp |
| RefSeq ORF | 423 bp |
| Locus ID | 20617 |
| Gene Summary | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).[UniProtKB/Swiss-Prot Function] |
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