NBR1 (NM_001291571) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	1A1-3B; IAI3B; M17S2; MIG19
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001291571, the custom clone sequence may differ by one or more nucleotides ATGGAACCACAGGTTACTCTAAATGTGACTTTTAAAAATGAAATTCAAAGCTTTCTGGTTTCTGATCCAG AAAATACAACTTGGGCTGATATCGAAGCTATGGTAAAAGTTTCATTTGATCTGAATACTATTCAAATAAA ATACCTGGATGAGGAAAATGAAGAGGTATCCATCAACAGTCAAGGAGAATATGAAGAAGCGCTTAAGATG GCAGTTAAACAGGGAAACCAACTGCAGATGCAAGTCCACGAAGGGCACCATGTCGTTGATGAAGCCCCAC CCCCAGTTGTAGGAGCAAAACGACTAGCTGCCAGGGCAGGGAAGAAGCCACTTGCACATTACTCTTCACT GGTGAGAGTCTTGGGATCAGACATGAAGACCCCAGAGGATCCTGCAGTGCAGTCGTTTCCACTTGTTCCA TGTGACACAGACCAGCCTCAAGACAAGCCCCCAGACTGGTTCACAAGCTACCTGGAGACGTTCAGAGAAC AAGTGGTTAACGAAACGGTTGAGAAGCTTGAACAGAAATTACATGAAAAGCTTGTCCTCCAGAACCCATC CTTGGGTTCTTGTCCCTCAGAAGTCTCAATGCCTACTTCAGAAGAAACATTGTTTTTGCCAGAAAACCAG TTCAGCTGGCATATTGCTTGCAACAACTGCCAAAGAAGGATTGTTGGTGTCCGCTACCAGTGTAGCCTAT GCCCATCCTACAATATCTGTGAAGATTGTGAAGCAGGGCCATATGGCCATGACACTAACCACGTCCTGCT GAAGTTGCGGAGACCTGTTGTGGGCTCCTCTGAACCGTTCTGTCACTCAAAGTACTCTACTCCTCGTCTT CCTGCTGCTCTGGAACAAGTCAGGCTCCAGAAACAGGTTGATAAGAACTTTCTTAAAGCAGAAAAGCAAA GGTTGCGAGCTGAGAAGAAACAACGTAAAGCAGAGGTCAAGGAACTTAAAAAGCAGCTTAAACTCCATAG GAAAATTCACCTGTGGAATTCAATCCATGGACTCCAGAGCCCCAAGTCTCCTTTAGGCCGACCTGAGAGC TTGCTCCAGTCTAATACCCTGATGCTCCCTTTGCAGCCCTGTACCTCCGTTATGCCAATGCTCAGTGCAG CATTTGTGGATGAGAATTTGCCTGATGGGACTCACCTTCAGCCAGGAACCAAGTTTATCAAACACTGGAG GATGAAAAATACAGGAAATGTAAAGTGGAGTGCAGACACAAAGCTCAAGTTCATGTGGGGAAACCTGACT TTGGCTTCCACAGAAAAGAAGGATGTTTTGGTTCCCTGCCTCAAGGCCGGCCATGTGGGAGTTGTATCTG TGGAGTTCATTGCCCCAGCCTTGGAGGGAACGTATACTTCCCATTGGCGTCTTTCTCACAAAGGCCAGCA ATTTGGGCCTCGGGTCTGGTGCAGTATCATAGTAGATCCTTTCCCCTCCGAAGAGAGCCCTGATAACATT GAAAAGGGCATGATCAGCTCAAGCAAAACTGATGATCTCACCTGCCAGCAAGAGGAAACTTTTCTTCTGG CTAAAGAAGAAAGACAGCTTGGTGAAGTGACTGAGCAGACAGAAGGGACAGCAGCCTGCATCCCACAGAA GGCAAAAAATGTTGCCAGTGAGAGGGAGCTCTACATCCCATCTGTGGATCTTCTGACTGCCCAGGACCTG CTGTCCTTTGAGCTGTTGGATATAAACATTGTTCAAGAGTTGGAGAGAGTGCCCCACAACACCCCTGTGG ATGTGACTCCCTGCATGTCTCCTCTGCCACATGACAGTCCTTTAATAGAGAAGCCAGGCTTGGGGCAGAT AGAGGAAGAGAATGAAGGGGCAGGATTTAAAGCACTTCCTGATTCTATGGTGTCAGTAAAGAGGAAGGCT GAGAACATTGCTTCTGTGGAGGAAGCAGAAGAAGACCTGAGTGGGACCCAGTTTGTGTGTGAGACAGTAA TCCGATCCCTTACCTTGGATGCTGCCCCAGACCACAACCCTCCTTGCAGACAGAAGTCCTTGCAGATGAC ATTTGCCTTGCCTGAAGGACCACTTGGAAATGAGAAGGAGGAGATTATCCATATCGCTGAGGAAGAAGCT GTCATGGAGGAGGAGGAGGATGAGGAGGATGAGGAGGAGGAGGATGAGCTCAAAGATGAAGTTCAAAGTC AGTCCTCTGCTTCCTCAGAGGATTACATCATCATCCTGCCTGAGTGCTTTGATACCAGCCGCCCCCTGGG GGATTCTATGTACAGCTCTGCGCTCTCACAGCCAGGCCTGGAGCGAGGTGCTGAAGGCAAGCCTGGGGTT GAGGCTGGGCAGGAACCAGCTGAGGCTGGGGAAAGACTCCCTGGAGGGGAGAACCAGCCACAGGAGCACA GCATAAGTGACATCCTCACGACCTCACAGACTCTGGAAACAGTGCCCCTAATCCCAGAGGTAGTGGAGCT TCCACCGTCACTGCCCAGGAGCTCTCCTTGTGTACATCATCATGGTTCCCCAGGAGTGGATTTACCAGTT ACCATACCAGAAGTTTCTTCAGTCCCTGATCAGATCAGAGGAGAGCCCAGAGGCTCATCAGGACTTGTAA ACAGCAGACAGAAGAGCTATGACCACTCAAGGCACCATCATGGGAGCAGCATTGCTGGAGGACTGGTGAA GGGGGCTTTGTCTGTTGCTGCCTCTGCATACAAGGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGGGT CTCTGGGGCTTGCTGTCATTCCTTCATCTGGCCAAAAAATGCTTCTTCCTGAAAGCCCCGAGTGAAGCAT TCTCCTGGTTCTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001291571
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001291571.1, NP_001278500.1
RefSeq Size	3387 bp
RefSeq ORF	2814 bp
Locus ID	4077
UniProt ID	Q14596
Protein Families	Druggable Genome
Gene Summary	The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] Transcript Variant: This variant (4) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

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