KCNH6 (NM_001278920) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ERG-2; ERG2; hERG-2; HERG2; Kv11.2
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001278920, the custom clone sequence may differ by one or more nucleotides ATGTTCATTCTCAACTTCGAGGACCTGGCCCAGCTCCTGGCCAAGTGCAGCAGCCGCAGCTTGTCCCAGC GCCTGTTGTCCCAGAGCTTCCTGGGCTCCGAGGGCTCTCATGGCAGGCCAGGCGGACCAGGGCCAGGCAC AGGCAGGGGCAAGTACAGGACCATCAGCCAGATCCCACAGTTCACGCTCAACTTCGTGGAGTTCAACTTG GAGAAGCACCGCTCCAGCTCCACCACGGAGATTGAGATCATCGCGCCCCATAAGGTGGTGGAGCGGACAC AGAACGTCACTGAGAAGGTCACCCAGGTCCTGTCCCTGGGCGCGGATGTGCTGCCGGAGTACAAGCTGCA GGCGCCGCGCATCCACCGCTGGACCATCCTGCACTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATC CTGCTGCTGGTCATCTACACGGCTGTCTTCACGCCCTACTCAGCCGCCTTCCTGCTCAGCGATCAGGACG AATCACGGCGTGGGGCCTGCAGCTATACCTGCAGTCCCCTCACTGTGGTGGATCTCATCGTGGACATCAT GTTCGTCGTGGACATCGTCATCAACTTCCGCACCACCTATGTCAACACCAATGATGAGGTGGTCAGCCAC CCCCGCCGCATCGCCGTCCACTACTTCAAGGGCTGGTTCCTCATTGACATGGTGGCCGCCATCCCTTTCG ACCTCCTGATCTTCCGCACTGGCTCCGATGAGACCACAACCCTGATTGGGCTATTGAAGACAGCGCGGCT GCTGCGGCTGGTGCGCGTAGCACGGAAGCTGGACCGCTACTCTGAGTATGGGGCGGCTGTGCTCTTCTTG CTCATGTGCACCTTCGCGCTCATAGCGCACTGGCTGGCCTGCATCTGGTACGCCATCGGCAATGTGGAGC GGCCCTACCTAGAACACAAGATCGGCTGGCTGGACAGCCTGGGTGTGCAGCTTGGCAAGCGCTACAACGG CAGCGACCCAGCCTCGGGCCCCTCGGTGCAGGACAAGTATGTCACAGCCCTCTACTTCACCTTCAGCAGC CTCACCAGCGTGGGCTTCGGCAATGTCTCGCCCAACACCAACTCCGAGAAGGTCTTCTCCATCTGCGTCA TGCTCATCGGCTCCCTGATGTACGCCAGCATCTTCGGGAACGTGTCCGCGATCATCCAGCGCCTGTACTC GGGCACCGCGCGCTACCACACGCAGATGCTGCGTGTCAAGGAGTTCATCCGCTTCCACCAGATCCCCAAC CCACTGCGCCAGCGCCTGGAGGAGTATTTCCAGCACGCCTGGTCCTACACCAATGGCATTGACATGAACG CGGTGCTGAAGGGCTTCCCCGAGTGCCTGCAGGCTGACATCTGCCTGCACCTGCACCGCGCACTGCTGCA GCACTGCCCAGCTTTCAGCGGCGCCGGCAAGGGCTGCCTGCGCGCGCTAGCCGTCAAGTTCAAGACCACC CACGCGCCGCCTGGGGACACGCTGGTGCACCTCGGCGACGTGCTCTCCACCCTCTACTTCATCTCCCGAG GCTCCATCGAGATCCTGCGCGACGACGTGGTCGTGGCCATCCTAGGAAAGAATGACATCTTTGGGGAACC CGTCAGCCTCCATGCCCAGCCAGGCAAGTCCAGTGCAGACGTGCGGGCTCTGACCTACTGCGACCTGCAC AAGATCCAGCGGGCAGATCTGCTGGAGGTGCTGGACATGTACCCGGCCTTTGCGGAGAGCTTCTGGAGTA AGCTGGAGGTCACCTTCAACCTGCGGGACGCAGCCGGGGGTCTCCACTCATCCCCCCGACAGGCTCCTGG CAGCCAAGACCACCAAGGTTTCTTTCTCAGTGACAACCAGTCAGATGCAGCCCCTCCCCTGAGCATCTCA GATGCATCTGGCCTCTGGCCTGAGCTACTGCAGGAAATGCCCCCAAGGCACAGCCCCCAAAGCCCTCAGG AAGACCCAGATTGCTGGCCTCTGAAGCTGGGCTCCAGGCTAGAGCAGCTCCAGGCCCAGATGAACAGGCT GGAGTCCCGCGTGTCCTCAGACCTCAGCCGCATCTTGCAGCTCCTCCAGAAGCCCATGCCCCAGGGCCAC GCCAGCTACATTCTGGAAGCCCCTGCCTCCAATGACCTGGCCTTGGTTCCTATAGCCTCGGAGACGACGA GTCCAGGGCCCAGGCTGCCCCAGGGCTTTCTGCCTCCTGCACAGACCCCAAGCTATGGAGACTTGGATGA CTGTAGTCCAAAGCACAGGAACTCCTCCCCCAGGATGCCTCACCTGGCTGTGGCAACGGACAAAACTCTG GCACCATCCTCAGAACAGGAACAGCCTGAGGGGCTCTGGCCACCCCTAGCCTCACCTCTACATCCCCTGG AAGTACAAGGACTCATCTGTGGTCCCTGCTTCTCCTCCCTCCCTGAACACCTTGGCTCTGTTCCCAAGCA GCTGGACTTCCAGAGACATGGCTCAGATCCTGGATTTGCAGGGAGTTGGGGCCACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001278920
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001278920.1, NP_001265849.1
RefSeq Size	3650 bp
RefSeq ORF	2508 bp
Locus ID	81033
UniProt ID	Q9H252
Protein Families	Druggable Genome, Ion Channels: Other, Transmembrane
Gene Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and is shorter, compared to isoform 1.

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