CORIN (NM_001278586) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ATC2; CRN; Lrp4; PEE5; TMPRSS10
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001278586, the custom clone sequence may differ by one or more nucleotides ATGAAACAGTCTCCTGCCCTCGCTCCGGAAGAGCGCTGCCGCAGAGCCGGGTCCCCAAAGCCGGTCTTGA GAGCTGATGACAATAACATGGGCAATGGCTGCTCTCAGAAGCTGGCGACTGCTAACCTCCTCCGGTTCCT ATTGCTGGTCCTGATTCCATGTATCTGTGCTCTCGTTCTCTTGCTGGTGATCCTGCTTTCCTATGTTGGA ACATTACAAAAGGTCTATTTTAAATCAAATGGGAGTGAACCTTTGGTCACTGATGGTGAAATCCAAGGGT CCGATGTTATTCTTACAAATACAATTTATAACCAGAGCACTGTGGTGTCTACTGCACATCCCGACCAACA CGTTCCAGCCTGGACTACGGATGCTTCTCTCCCAGGGGACCAAAGTCACAGGAATACAAGTGCCTGTATG AACATCACCCACAGCCAGTGTCAGATGCTGCCCTACCACGCCACGCTGACACCTCTCCTCTCAGTTGTCA GAAACATGGAAATGGAAAAGTTCCTCAAGTTTTTCACATATCTCCATCGCCTCAGTTGCTATCAACATAT CATGCTGTTTGGCTGTACCCTCGCCTTCCCTGAGTGCATCATTGATGGCGATGACAGTCATGGACTCCTG CCCTGTAGGTCCTTCTGTGAGGCTGCAAAAGAAGGCTGTGAATCAGTCCTGGGGATGGTGAATTACTCCT GGCCGGATTTCCTCAGATGCTCCCAGTTTAGAAACCAAACTGAAAGCAGCAATGTCAGCAGAATTTGCTT CTCACCTCAGCAGGAAAACGGAAAGCAATTGCTCTGTGGAAGGGGTGAGAACTTTCTGTGTGCCAGTGGA ATCTGCATCCCCGGGAAACTGCAATGTAATGGCTACAACGACTGTGACGACTGGAGTGACGAGGCTCATT GCAACTGCAGCGAGAATCTGTTTCACTGTCACACAGGCAAGTGCCTTAATTACAGCCTTGTGTGTGATGG ATATGATGACTGTGGGGATTTGAGTGATGAGCAAAACTGTGCCTGTCACAGCCAGGGTCTGGTGGAATGC AGAAATGGACAATGTATCCCCAGCACGTTTCAATGTGATGGTGACGAGGACTGCAAGGATGGGAGTGATG AGGAGAACTGCAGCGTCATTCAGACTTCATGTCAAGAAGGAGACCAAAGATGCCTCTACAATCCCTGCCT TGATTCATGTGGTGGTAGCTCTCTCTGTGACCCGAACAACAGTCTGAATAACTGTAGTCAATGTGAACCA ATTACATTGGAACTCTGCATGAATTTGCCCTACAACAGTACAAGTTATCCAAATTATTTTGGCCACAGGA CTCAAAAGGAAGCATCCATCAGCTGGGAGTCTTCTCTTTTCCCTGCACTTGTTCAAACCAACTGTTATAA ATACCTCATGTTCTTTTCTTGCACCATTTTGGTACCAAAATGTGATGTGAATACAGGCGAGCATATCCCT CCTTGCAGGGCATTGTGTGAACACTCTAAAGAACGCTGTGAGTCTGTTCTTGGGATTGTGGGCCTACAGT GGCCTGAAGACACAGATTGCAGTCAATTTCCAGAGGAAAATTCAGACAATCAAACCTGCCTGATGCCTGA TGAATATGTGGAAGAATGCTCACCTAGTCATTTCAAGTGCCGCTCAGGACAGTGTGTTCTGGCTTCCAGA AGATGTGATGGCCAGGCCGACTGTGACGATGACAGTGATGAGGAAAACTGTGGTTGTAAAGAGAGAGATC TTTGGGAATGTCCATCCAATAAACAATGTTTGAAGCACACAGTGATCTGCGATGGGTTCCCAGACTGCCC TGATTACATGGACGAGAAAAACTGCTCATTTTGCCAAGATGATGAGCTGGAATGTGCAAACCATGCGTGT GTGTCACGTGACCTGTGGTGTGATGGTGAAGCCGACTGCTCAGACAGTTCAGATGAATGGGACTGTGGTG AGCTACTTGTTTCTGCCATCTGTTGTACTCTCTCATGCCTGTCAGCCACTGAAGCTGAATGGATCCTAAA TTACTTCCTGGATTTTACTGACCAAGTTCATCTATTTTGTTTTACTGTTATAAAAGCTGATAGTGCTGAT CTATGTGTGTTATTTCCAACTCACAGAAAATTTCCCCACGAAGCTACTTCTCTATTTGAAATATCTATAT TGTATGGAAAAACGTTTGGGTTCAAAATGTTGTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001278586
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001278586.1, NP_001265515.1
RefSeq Size	2442 bp
RefSeq ORF	2205 bp
Locus ID	10699
Protein Families	Druggable Genome, Protease, Transmembrane
Gene Summary	This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] Transcript Variant: This variant (3) lacks an in-frame internal exon and multiple 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform 1.

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