AATK (NM_004920) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC333284 representing NM_004920. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCCAAGCAGCCTGGGCGCTCAGTGCAGCTCCTCAAGTCCACAGACGTGGGCCGGCACAGCCTCCTG TACCTGAAGGAAATCGGCCGTGGCTGGTTCGGGAAGGTGTTCCTGGGGGAGGTGAACTCTGGCATCAGC AGTGCCCAGGTGGTGGTGAAGGAGCTGCAGGCTAGTGCCAGCGTGCAGGAGCAGATGCAGTTCCTGGAG GAGGTGCAGCCCTACAGGGCCCTGAAGCACAGCAACCTGCTCCAGTGCCTGGCCCAGTGCGCCGAGGTG ACGCCCTACCTGCTGGTGATGGAGTTCTGCCCACTGGGGGACCTCAAGGGCTACCTGCGGAGCTGCCGG GTGGCGGAGTCCATGGCTCCCGACCCCCGGACCCTGCAGCGCATGGCCTGTGAGGTGGCCTGTGGCGTC CTGCACCTTCATCGCAACAATTTCGTGCACAGCGACCTGGCCCTGCGGAACTGCCTGCTCACGGCTGAC CTGACGGTGAAGATTGGTGACTATGGCCTGGCTCACTGCAAGTACAGAGAGGACTACTTCGTGACTGCC GACCAGCTGTGGGTGCCTCTGCGCTGGATCGCGCCAGAGCTGGTGGACGAGGTGCATAGCAACCTGCTC GTCGTGGACCAGACCAAGAGCGGGAATGTGTGGTCCCTGGGCGTGACCATCTGGGAGCTCTTTGAGCTG GGCACGCAGCCCTATCCCCAGCACTCGGACCAGCAGGTGCTGGCGTACACGGTCCGGGAGCAGCAGCTC AAGCTGCCCAAGCCCCAGCTGCAGCTGACCCTGTCGGACCGCTGGTACGAGGTGATGCAGTTCTGCTGG CTGCAGCCCGAGCAGCGGCCCACAGCCGAGGAGGTGCACCTGCTGCTGTCCTACCTGTGTGCCAAGGGC GCCACCGAAGCAGAGGAGGAGTTTGAACGGCGCTGGCGCTCTCTGCGGCCCGGCGGGGGCGGCGTGGGG CCCGGGCCCGGTGCGGCGGGGCCCATGCTGGGCGGCGTGGTGGAGCTCGCCGCTGCCTCGTCCTTCCCG CTGCTGGAGCAGTTCGCGGGCGACGGCTTCCACGCGGACGGCGACGACGTGCTGACGGTGACCGAGACC AGCCGAGGCCTCAATTTTGAGTACAAGTGGGAGGCGGGCCGCGGCGCGGAGGCCTTCCCGGCCACGCTG AGCCCTGGCCGCACCGCACGCCTGCAGGAGCTGTGCGCCCCCGACGGCGCGCCCCCGGGCGTGGTTCCG GTGCTCAGCGCGCACAGCCCGTCGCTGGGCAGCGAGTACTTCATCCGCCTAGAGGAGGCCGCACCCGCC GCCGGCCACGACCCTGACTGCGCCGGCTGCGCCCCCAGTCCACCTGCCACCGCGGACCAGGACGACGAC TCTGACGGCAGCACCGCCGCCTCGCTGGCCATGGAGCCGCTGCTGGGCCACGGGCCACCCGTCGACGTC CCCTGGGGCCGCGGCGACCACTACCCTCGCAGAAGCTTGGCGCGGGACCCGCTCTGCCCCTCACGCTCT CCCTCGCCCTCGGCGGGGCCCCTGAGTCTGGCGGAGGGAGGAGCGGAGGATGCAGACTGGGGCGTGGCC GCCTTCTGTCCTGCCTTCTTCGAGGACCCACTGGGCACGTCCCCTTTGGGGAGCTCAGGGGCGCCCCCG CTGCCGCTGACTGGCGAGGATGAGCTAGAGGAGGTGGGAGCGCGGAGGGCCGCCCAGCGCGGGCACTGG CGCTCCAACGTGTCAGCCAACAACAACAGCGGCAGCCGCTGTCCAGAGTCCTGGGACCCCGTCTCTGCG GGCGGCCACGCTGAGGGCTGCCCCAGTCCAAAGCAGACCCCACGGGCCTCCCCCGAGCCGGGGTACCCT GGAGAGCCTCTGCTTGGGCTCCAGGCAGCCTCTGCCCAGGAGCCAGGCTGCTGCCCCGGCCTCCCTCAT CTATGCTCTGCCCAGGGCCTGGCACCTGCTCCCTGCCTGGTTACACCCTCCTGGACAGAGACAGCCAGT AGTGGGGGTGACCACCCGCAGGCAGAGCCCAAGCTTGCCACGGAGGCTGAGGGCACTACCGGACCCCGC CTGCCCCTTCCTTCCGTCCCCTCCCCATCCCAGGAGGGAGCCCCACTTCCCTCGGAGGAGGCCAGTGCC CCCGACGCCCCTGATGCCCTGCCTGACTCTCCCACGCCTGCTACTGGTGGCGAGGTGTCTGCCATCAAG CTGGCTTCTGCCCTGAATGGCAGCAGCAGCTCTCCCGAGGTGGAGGCACCCAGCAGTGAGGATGAGGAC ACGGCCGAGGCCACCTCAGGCATCTTCACCGACACGTCCAGCGACGGCCTGCAGGCCAGGAGGCCGGAT GTGGTGCCAGCCTTCCGCTCTCTGCAGAAGCAGGTGGGGACCCCCGACTCCCTGGACTCCCTGGACATC CCGTCCTCAGCCAGTGATGGTGGCTATGAGGTCTTCAGCCCGTCGGCCACTGGCCCCTCTGGAGGGCAG CCGCGAGCGCTGGACAGTGGCTATGACACCGAGAACTATGAGTCCCCTGAGTTTGTGCTCAAGGAGGCG CAGGAAGGGTGTGAGCCCCAGGCCTTTGCGGAGCTGGCCTCAGAGGGTGAGGGCCCCGGGCCCGAGACA CGGCTCTCCACCTCCCTCAGTGGCCTCAACGAGAAGAATCCCTACCGAGACTCTGCCTACTTCTCAGAC CTCGAGGCTGAGGCCGAGGCCACCTCAGGCCCAGAGAAGAAGTGCGGCGGGGACCGAGCCCCCGGGCCA GAGCTGGGCCTGCCGAGCACTGGGCAGCCGTCTGAGCAGGTCTGTCTCAGGCCTGGGGTTTCCGGGGAG GCACAAGGCTCTGGCCCCGGGGAGGTGCTGCCCCCACTGCTGCAGCTTGAAGGGTCCTCCCCAGAGCCC AGCACCTGCCCCTCGGGCCTGGTCCCAGAGCCTCCGGAGCCCCAAGGCCCAGCCAAGGTGCGGCCTGGG CCCAGCCCCAGCTGCTCCCAGTTTTTCCTGCTGACCCCGGTTCCGCTGAGATCAGAAGGCAACAGCTCT GAGTTCCAGGGGCCCCCAGGACTGTTGTCAGGGCCGGCCCCACAAAAGCGGATGGGGGGCCCAGGCACC CCCAGAGCCCCACTCCGCCTGGCTCTGCCCGGCCTCCCTGCGGCCTTGGAGGGCCGGCCGGAGGAGGAG GAGGAGGACAGTGAGGACAGCGACGAGTCTGACGAGGAGCTCCGCTGCTACAGCGTCCAGGAGCCTAGC GAGGACAGCGAAGAGGAGGCGCCGGCGGTGCCCGTGGTGGTGGCTGAGAGCCAGAGCGCGCGCAACCTG CGCAGCCTGCTCAAGATGCCCAGCCTGCTGTCCGAGACCTTCTGCGAGGACCTGGAACGCAAGAAGAAG GCCGTGTCCTTCTTCGACGACGTCACCGTCTACCTCTTTGACCAGGAAAGCCCCACCCGGGAGCTCGGG GAGCCCTTCCCGGGCGCCAAGGAATCGCCCCCTACGTTCCTTAGGGGGAGCCCCGGCTCTCCCAGCGCC CCCAACCGGCCGCAGCAGGCTGATGGCTCCCCAAATGGCTCCACAGCGGAAGAGGGTGGTGGGTTCGCG TGGGACGACGACTTCCCGCTGATGACGGCCAAGGCAGCCTTCGCCATGGCCCTAGACCCGGCCGCACCC GCCCCGGCTGCGCCCACGCCCACGCCCGCTCCCTTCTCGCGCTTCACGGTGTCGCCCGCGCCCACGTCC CGCTTCTCCATCACGCACGTGTCTGACTCGGACGCCGAGTCCAAGAGAGGACCTGAAGCTGGTGCCGGG GGTGAGAGTAAAGAGGCTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_004920
Insert Size	3816 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_004920.2
RefSeq Size	5105 bp
RefSeq ORF	3816 bp
Locus ID	9625
UniProt ID	Q6ZMQ8
Protein Families	Druggable Genome, Protein Kinase
MW	133.8 kDa
Gene Summary	The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

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