NALP6 (NLRP6) (NM_001276700) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC333261 representing NM_001276700. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGACCAGCCAGAGGCCCCCTGCTCCAGCACGGGGCCGCGCCTCGCGGTGGCCCGCGAGCTGCTCCTG GCTGCGCTGGAGGAACTGAGCCAAGAGCAGCTGAAGCGCTTCCGCCACAAGCTGCGCGACGTGGGCCCG GACGGACGCAGCATCCCGTGGGGGCGGCTGGAGCGCGCGGACGCCGTGGACCTCGCGGAGCAGCTGGCC CAGTTCTACGGCCCGGAGCCTGCCCTGGAGGTGGCCCGCAAGACCCTCAAGAGGGCGGACGCGCGCGAC GTGGCGGCGCAGCTCCAGGAGCGGCGGCTGCAGCGGCTCGGGCTCGGCTCCGGGACGCTGCTCTCCGTG TCCGAGTACAAGAAGAAGTACCGGGAGCACGTGCTGCAGCTGCACGCTCGGGTGAAGGAGAGGAACGCC CGCTCCGTGAAGATCACCAAGCGCTTCACCAAGCTGCTCATCGCGCCCGAGAGCGCCGCCCCGGAGGAG GCGATGGGGCCCGCGGAAGAGCCTGAGCCGGGGCGCGCGCGGCGCTCGGACACGCACACTTTCAACCGC CTCTTCCGCCGCGACGAGGAGGGCCGGCGGCCGCTGACCGTGGTGCTGCAGGGCCCGGCGGGCATCGGC AAGACCATGGCGGCCAAAAAGATCCTGTACGACTGGGCGGCGGGCAAGCTGTACCAGGGCCAGGTGGAC TTCGCCTTCTTCATGCCCTGCGGCGAGCTGCTGGAGAGGCCGGGCACGCGCAGCCTGGCTGACCTGATC CTGGACCAGTGCCCCGACCGCGGCGCGCCGGTGCCGCAGATGCTGGCCCAGCCGCAGCGGCTGCTCTTC ATCCTGGACGGCGCGGACGAGCTGCCGGCGCTGGGGGGCCCCGAGGCCGCGCCCTGCACAGACCCCTTC GAGGCGGCGAGCGGCGCGCGGGTGCTAGGCGGGCTGCTGAGCAAGGCGCTGCTGCCCACGGCCCTCCTG CTGGTGACCACGCGCGCCGCCGCCCCCGGGAGGCTGCAGGGCCGCCTGTGTTCCCCGCAGTGCGCCGAG GTGCGCGGCTTCTCCGACAAGGACAAGAAGAAGTATTTCTACAAGTATTTCCGGGATGAGAGGAGGGCC GAGCGCGCCTACCGCTTCGTGAAGGAGAACGAGACGCTGTTCGCGCTGTGCTTCGTGCCCTTCGTGTGC TGGATCGTGTGCACCGTGCTGCGCCAGCAGCTGGAGCTCGGTCGGGACCTGTCGCGCACGTCCAAGACC ACCACGTCAGTGTACCTGCTTTTCATCACCAGCGTTCTGAGCTCGGCTCCGGTAGCCGACGGGCCCCGG TTGCAGGGCGACCTGCGCAATCTGTGCCGCCTGGCCCGCGAGGGCGTCCTCGGACGCAGGGCGCAGTTT GCCGAGAAGGAACTGGAGCAACTGGAGCTTCGTGGCTCCAAAGTGCAGACGCTGTTTCTCAGCAAAAAG GAGCTGCCGGGCGTGCTGGAGACAGAGGTCACCTACCAGTTCATCGACCAGAGCTTCCAGGAGTTCCTC GCGGCACTGTCCTACCTGCTGGAGGACGGCGGGGTGCCCAGGACCGCGGCTGGCGGCGTTGGGACACTC CTGCGTGGGGACGCCCAGCCGCACAGCCACTTGGTGCTCACCACGCGCTTCCTCTTCGGACTGCTGAGC GCGGAGCGGATGCGCGACATCGAGCGCCACTTCGGCTGCATGGTTTCAGAGCGTGTGAAGCAGGAGGCC CTGCGGTGGGTGCAGGGACAGGGACAGGGCTGCCCCGGAGTGGCACCAGAGGTGACCGAGGGGGCCAAA GGGCTCGAGGACACCGAAGAGCCAGAGGAGGAGGAGGAGGGAGAGGAGCCCAACTACCCACTGGAGTTG CTGTACTGCCTGTACGAGACGCAGGAGGACGCGTTTGTGCGCCAAGCCCTGTGCCGGTTCCCGGAGCTG GCGCTGCAGCGAGTGCGCTTCTGCCGCATGGACGTGGCTGTTCTGAGCTACTGCGTGAGGTGCTGCCCT GCTGGACAGGCACTGCGGCTGATCAGCTGCAGATTGGTTGCTGCGCAGGAGAAGAAGAAGAAGAGCCTG GGGAAGCGGCTCCAGGCCAGCCTGGGTGGCGGCAGTTCTCAAGGCACCACAAAACAACTGCCAGCCTCC CTTCTTCATCCACTCTTTCAGGCAATGACTGACCCACTGTGCCATCTGAGCAGCCTCACGCTGTCCCAC TGCAAACTCCCTGACGCGGTCTGCCGAGACCTTTCTGAGGCCCTGAGGGCAGCCCCCGCACTGACGGAG CTGGGCCTCCTCCACAACAGGCTCAGTGAGGCGGGACTGCGTATGCTGAGTGAGGGCCTAGCCTGGCCG CAGTGCAGGGTGCAGACGGTCAGGGTACAGCTGCCTGACCCCCAGCGAGGGCTCCAGTACCTGGTGGGT ATGCTTCGGCAGAGCCCTGCCCTGACCACCCTGGATCTCAGCGGCTGCCAACTGCCCGCCCCCATGGTG ACCTACCTGTGTGCAGTCCTGCAGCACCAGGGATGCGGCCTGCAGACCCTCAGTCTGGCCTCTGTGGAG CTGAGCGAGCAGTCACTACAGGAGCTTCAGGCTGTGAAGAGAGCAAAGCCGGATCTGGTCATCACACAC CCAGCGCTGGACGGCCACCCACAACCTCCCAAGGAACTCATCTCGACCTTCTGA
Restriction Sites	SgfI-RsrII
ACCN	NM_001276700
Insert Size	2676 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001276700.1
RefSeq Size	2760 bp
RefSeq ORF	2676 bp
Locus ID	171389
UniProt ID	P59044
MW	98.7 kDa
Gene Summary	The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] Transcript Variant: This variant (2) uses an alternate in-frame exon at the 5' end of an exon compared to variant 1. The resulting isoform (2) lacks a single internal aa compared to isoform 1.

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