INT11 (CPSF3L) (NM_001256462) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CPSF3L; CPSF73L; INT11; RC-68; RC68
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330434 representing NM_001256462. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGCCTGAGATCAGAGTCACGCCCTTGGGTGCCTGCCCTGTGCTGTCCTGGAACCTGGTCCTTCCACCG GGCAGGGGGTCGAGGGCACCTTCCAGCACAGACACCAGGACGGGATTCCATGTCCTCCCCCATGGCGTG AATGATGAGCTGGAGATCAAGGCCTACTATGCAGGCCACGTGCTGGGGGCAGCCATGTTCCAGATTAAA GTGGGCTCAGAGTCTGTGGTCTACACGGGTGATTATAACATGACCCCAGACCGACACTTAGGAGCTGCC TGGATTGACAAGTGCCGCCCCAACCTGCTCATCACAGAGTCCACGTACGCCACGACCATCCGTGACTCC AAGCGCTGCCGGGAGCGAGACTTCCTGAAGAAAGTCCACGAGACCGTGGAGCGTGGTGGGAAGGTGCTG ATACCTGTGTTCGCGCTGGGCCGCGCCCAGGAGCTCTGCATCCTCCTGGAGACCTTCTGGGAGCGCATG AACCTGAAGGTGCCCATCTACTTCTCCACGGGGCTGACCGAGAAGGCCAACCACTACTACAAGCTGTTC ATCCCCTGGACCAACCAGAAGATCCGCAAGACTTTCGTGCAGAGGAACATGTTTGAGTTCAAGCACATC AAGGCCTTCGACCGGGCTTTTGCTGACAACCCAGGACCGATGGTTGTGTTTGCCACGCCAGGAATGCTG CACGCTGGGCAGTCCCTGCAGATCTTCCGGAAATGGGCCGGAAACGAAAAGAACATGGTCATCATGCCC GGCTACTGCGTGCAGGGCACCGTCGGCCACAAGATCCTCAGCGGGCAGCGGAAGCTCGAGATGGAGGGG CGGCAGGTGCTGGAGGTCAAGATGCAGGTGGAGTACATGTCATTCAGCGCACACGCGGACGCCAAGGGC ATCATGCAGCTGGTGGGCCAGGCAGAGCCGGAGAGCGTGCTGCTGGTGCATGGCGAGGCCAAGAAGATG GAGTTCCTGAAGCAGAAGATCGAGCAGGAGCTCCGGGTCAACTGCTACATGCCGGCCAATGGCGAGACG GTGACGCTGCCCACAAGCCCCAGCATCCCCGTAGGCATCTCGCTGGGGCTGCTGAAGCGGGAGATGGCG CAGGGGCTGCTCCCTGAGGCCAAGAAGCCTCGGCTCCTGCACGGCACCCTGATCATGAAGGACAGCAAC TTCCGGCTGGTGTCCTCAGAGCAAGCCCTCAAAGAGCTGGGTCTGGCTGAGCACCAGCTGCGCTTCACC TGCCGCGTGCACCTGCATGACACACGCAAGGAGCAGGAGACGGCATTGCGCGTCTACAGCCACCTCAAG AGCGTCCTGAAGGACCACTGTGTGCAGCACCTCCCAGACGGCTCTGTGACTGTGGAGTCCGTCCTCCTC CAGGCCGCCGCCCCTTCTGAGGACCCAGGCACCAAGGTGCTGCTGGTCTCCTGGACCTACCAGGACGAG GAGCTGGGGAGCTTCCTCACATCTCTGCTGAAGAAGGGCCTCCCCCAGGCCCCCAGCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001256462
Insert Size	1509 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001256462.1
RefSeq Size	1874 bp
RefSeq ORF	1509 bp
Locus ID	54973
UniProt ID	Q5TA45
MW	56.3 kDa
Gene Summary	The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Transcript Variant: This variant (4) lacks several exons which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus when it is compared to isoform 1.

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