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PLOD3 (NM_001084) Human Untagged Clone
CAT＃: SC324563
PLOD3 (untagged)-Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3)
CNY 8,120.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | LH3 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001084.4
GCTTCCACATGTGTCAAGCGGCTGGCTCAGCCCAGAGTCCCTGTCTCCCGCCCGCCGGCC
CGAGCCGCCGCCCCTCCCCCGCCTCCCGTGCGCCCGGGACAATCCTCGCCTTGTCTGTGG CGCCGGCATCTGGAGCTTTCTGTAGCCTCCGGATACGCCTTTTTTTCAGGGCGTAGCCCC AGCCAAGCTGCTCCCCGCGGCGGCCGCACAGCAGCCCGAGCGCCCCCTTTCCGGAGCTCC CCTCCGGAGCTGGGATCCAGGCGCGTAGCGGAGATCCCAGGATCCTGGGTGCTGTCTGGG CCCGCTCCCCACCATGACCTCCTCGGGGCCTGGACCCCGGTTCCTGCTGCTGCTGCCGCT GCTGCTGCCCCCTGCGGCCTCAGCCTCCGACCGGCCCCGGGGCCGAGACCCGGTCAACCC AGAGAAGCTGCTGGTGATCACTGTGGCCACAGCTGAAACCGAGGGGTACCTGCGTTTCCT GCGCTCTGCGGAGTTCTTCAACTACACTGTGCGGACCCTGGGCCTGGGAGAGGAGTGGCG AGGGGGTGATGTGGCTCGAACAGTTGGTGGAGGACAGAAGGTCCGGTGGTTAAAGAAGGA AATGGAGAAATACGCTGACCGGGAGGATATGATCATCATGTTTGTGGATAGCTACGACGT GATTCTGGCCGGCAGCCCCACAGAGCTGCTGAAGAAGTTCGTCCAGAGTGGCAGCCGCCT GCTCTTCTCTGCAGAGAGCTTCTGCTGGCCCGAGTGGGGGCTGGCGGAGCAGTACCCTGA GGTGGGCACGGGGAAGCGCTTCCTCAATTCTGGTGGATTCATCGGTTTTGCCACCACCAT CCACCAAATCGTGCGCCAGTGGAAGTACAAGGATGATGACGACGACCAGCTGTTCTACAC ACGGCTCTACCTGGACCCAGGACTGAGGGAGAAACTCAGCCTTAATCTGGATCATAAGTC TCGGATCTTTCAGAACCTCAACGGGGCTTTAGATGAAGTGGTTTTAAAGTTTGATCGGAA CCGTGTGCGTATCCGGAACGTGGCCTACGACACGCTCCCCATTGTGGTCCATGGAAACGG TCCCACTAAGCTGCAGCTCAACTACCTGGGAAACTACGTCCCCAATGGCTGGACTCCTGA GGGAGGCTGTGGCTTCTGCAACCAGGACCGGAGGACACTCCCGGGGGGGCAGCCTCCCCC CCGGGTGTTTCTGGCCGTGTTTGTGGAACAGCCTACTCCGTTTCTGCCCCGCTTCCTGCA GCGGCTGCTACTCCTGGACTATCCCCCCGACAGGGTCACCCTTTTCCTGCACAACAACGA GGTCTTCCATGAACCCCACATCGCTGACTCCTGGCCGCAGCTCCAGGACCACTTCTCAGC TGTGAAGCTCGTGGGGCCGGAGGAGGCTCTGAGCCCAGGCGAGGCCAGGGACATGGCCAT GGACCTGTGTCGGCAGGACCCCGAGTGTGAGTTCTACTTCAGCCTGGACGCCGACGCTGT CCTCACCAACCTGCAGACCCTGCGTATCCTCATTGAGGAGAACAGGAAGGTGATCGCCCC CATGCTGTCCCGCCACGGCAAGCTGTGGTCCAACTTCTGGGGCGCCCTGAGCCCCGATGA GTACTACGCCCGCTCCGAGGACTACGTGGAGCTGGTGCAGCGGAAGCGAGTGGGTGTGTG GAATGTACCATACATCTCCCAGGCCTATGTGATCCGGGGTGATACCCTGCGGATGGAGCT GCCCCAGAGGGATGTGTTCTCGGGCAGTGACACAGACCCGGACATGGCCTTCTGTAAGAG CTTTCGAGACAAGGGCATCTTCCTCCATCTGAGCAATCAGCATGAATTTGGCCGGCTCCT GGCCACTTCCAGATACGACACGGAGCACCTGCACCCCGACCTCTGGCAGATCTTCGACAA CCCCGTCGACTGGAAGGAGCAGTACATCCACGAGAACTACAGCCGGGCCCTGGAAGGGGA AGGAATCGTGGAGCAGCCATGCCCGGACGTGTACTGGTTCCCACTGCTGTCAGAACAAAT GTGTGATGAGCTGGTGGCAGAGATGGAGCACTACGGCCAGTGGTCAGGCGGCCGGCATGA GGATTCAAGGCTGGCTGGAGGCTACGAGAATGTGCCCACCGTGGACATCCACATGAAGCA GGTGGGGTACGAGGACCAGTGGCTGCAGCTGCTGCGGACGTATGTGGGCCCCATGACCGA GAGCCTGTTTCCCGGTTACCACACCAAGGCGCGGGCGGTGATGAACTTTGTGGTTCGCTA CCGGCCAGACGAGCAGCCGTCTCTGCGGCCACACCACGACTCATCCACCTTCACCCTCAA CGTTGCCCTCAACCACAAGGGCCTGGACTATGAGGGAGGTGGCTGCCGCTTCCTGCGCTA CGACTGTGTGATCTCCTCCCCGAGGAAGGGCTGGGCACTCCTGCACCCCGGCCGCCTCAC CCACTACCACGAGGGGCTGCCAACGACCTGGGGCACACGCTACATCATGGTGTCCTTTGT CGACCCCTGACACTCAACCACTCTGCCAAACCTGCCCTGCCATTGTGCCTTTTTAGGGGG CCTGGCCCCCGTCCTGGGAGTTGGGGGATGGGTCTCTCTGTCTCCCCACTTCCTGAGTTC ATGTTCCGCGTGCCTGAACTGAATATGTCACCTTGCTCCCAAGACACGGCCCTCTCAGGA AGCTCCCGGAGTCCCCGCCTCTCTCCTCCGCCCACAGGGGTTCGTGGGCACAGGGCTTCT GGGGACTCCCCGCGTGATAAATTATTAATGTTCCGCAGTCTCACTCTGAATAAAGGACAG TTTGTAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001084 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001084.4, NP_001075.1 |
| RefSeq Size | 2995 bp |
| RefSeq ORF | 2217 bp |
| Locus ID | 8985 |
| UniProt ID | O60568 |
| Domains | 2OG-FeII_Oxy, P4Hc |
| Protein Pathways | Lysine degradation |
| Gene Summary | The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
,null,
Molecular and cellular probes
,PubMed ID 32585183
[PLOD3]
|
|
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway
,Baek, JH;Yun, HS;Kwon, GT;Lee, J;Kim, JY;Jo, Y;Cho, JM;Lee, CW;Song, JY;Ahn, J;Kim, JS;Kim, EH;Hwang, SG;,
Cell Death Dis
,PubMed ID 30770789
[PLOD3]
|
|
PLOD3 promotes lung metastasis via regulation of STAT3
,Baek, JH;Yun, HS;Kwon, GT;Kim, JY;Lee, CW;Song, JY;Um, HD;Kang, CM;Park, JK;Kim, JS;Kim, EH;Hwang, SG;,
Cell Death Dis
,PubMed ID 30442941
[PLOD3]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203445 | PLOD3 (Myc-DDK-tagged)-Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) |
CNY 8,104.00 |
|
| RC203445L3 | Lenti-ORF clone of PLOD3 (Myc-DDK-tagged)-Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) |
CNY 7,700.00 |
|
| RC203445L4 | Lenti-ORF clone of PLOD3 (mGFP-tagged)-Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) |
CNY 7,700.00 |
|
| RG203445 | PLOD3 (tGFP-tagged) - Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) |
CNY 6,370.00 |
|
| SC119470 | PLOD3 (untagged)-Human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) |
CNY 8,120.00 |
