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KSR2 (NM_173598) Human Untagged Clone
CAT＃: SC318393
KSR2 (untagged)-Human kinase suppressor of ras 2 (KSR2)
CNY 6,752.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_173598 edited
ACAGTTGGTACCGCCACCATGATAGACTTGAGCATCTCCAACCTGGAAGGGCTTAGGACC AAATGTGCTACCTCCAACGACCTCACACAAAAAGAAATCCGGACCCTGGAGAGCAAGCTG GTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAAC GCGGAGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAG GAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGAGCCTGGAGGACCTCTTGGAGATGACG GATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGC CTCAACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAA CAAGACTGGACCATCCAGTGGCCCACCACAGAGACGGGGAAGGAGAACAATCCCGTGTGC CCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCC AAGTGCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCAC GTGGACAGGCTTACCGTGGACGCCTACCCGGGCTTGTGCCCGCCCCCGCCACTGGAGTCG GGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGC ACCCCCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAAC AAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCTCCCGAAAACTGATACACTTGATCCCG GGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGAC GAGGCCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGC AGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGCAGCGCTCCCCGCTGCTGTCCGAGCGC TCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCAC ACTGAGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCT CGCAGAGATCTTGGCAACTCCATCAAGCACAGGTTTTCCACCAAGTACTGGATGTCTCAG ACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTA AAGTGCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGA GGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCGTTCCGTGTGACATCAACAACCCTCTA CGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAA ATCAACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCC ACGACGTCCTCCACGCCCTCCTCGCCAGCACCCCCCCTCCCTCCTAGTGCCACGCCGCCT TCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCA TCCCACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAG ACGCCGACCCGGGCGCCCCAGGTCATCCTGCATCCGGTGACCTCGAATCCAATCTTGGAA GGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGAT GAGGCCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGG AGCTTCCCACGCAAGGCCAGCCAGACCAGCATCTTCCTTCAGGAGTGGGACATCCCCTTT GAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGC CGCTGGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAG CTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACAGGCAGACACGGCATGAGAACGTGGTG CTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAG GGACGGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACC AGGCAGATTGCTCAAGAAATTGTGAAGGGCATGGGCTACCTCCACGCCAAGGGAATCCTA CACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGAC TTTGGACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGC ATCCAGAATGGCTGGCTATGCCACCTGGCACCAGAGATCATCCGCCAGCTGTCCCCCGAC ACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATC TGGTATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATC TGGCAAATGGGCACAGGCATGAAACCCAACCTCAGCCAGATTGGCATGGGAAAAGAAATC TCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAG CTCATGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACAT TTCTGGAAGTCTGCAGAGCTGTGAGGTTTGTCAAGGGC |
| Restriction Sites | Please inquire |
| ACCN | NM_173598 |
| Insert Size | 2800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_173598.4, NP_775869.3 |
| RefSeq Size | 17008 bp |
| RefSeq ORF | 2766 bp |
| Locus ID | 283455 |
| UniProt ID | Q6VAB6 |
| Protein Families | Druggable Genome, Protein Kinase |
| Gene Summary | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.[UniProtKB/Swiss-Prot Function] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
,null,
Cell
,PubMed ID 24209692
[KSR2]
|
|
KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
,Pearce, LR;Atanassova, N;Banton, MC;Bottomley, B;,
[KSR2]
|
Documents
| Product Manuals |
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC211665 | KSR2 (Myc-DDK-tagged)-Human kinase suppressor of ras 2 (KSR2) |
CNY 6,744.00 |
|
| RC211665L1 | Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), Myc-DDK-tagged |
CNY 9,144.00 |
|
| RC211665L2 | Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), mGFP tagged |
CNY 9,030.00 |
|
| RC211665L3 | Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), Myc-DDK-tagged |
CNY 9,144.00 |
|
| RC211665L4 | Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), mGFP tagged |
CNY 9,144.00 |
|
| RG211665 | KSR2 (tGFP-tagged) - Human kinase suppressor of ras 2 (KSR2) |
CNY 7,890.00 |
|
| SC306873 | KSR2 (untagged)-Human kinase suppressor of ras 2 (KSR2) |
CNY 17,670.00 |
