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PLEKHM2 (NM_015164) Human Untagged Clone
CAT＃: SC316442
PLEKHM2 (untagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
CNY 19,760.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SKIP |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC316442 representing NM_015164.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAGCCGGGGGAGGTGAAGGACCGGATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGTTGCAGAGC TATTTTGCTGCATGTGAGGATGAGATCCCTGCCATCCGGAACCATGACAAGGTCCTACAGCGTCTGTGT GAGCACCTGGACCACGCCCTGCTGTACGGACTGCAAGACCTCTCCTCTGGCTACTGGGTGCTCGTGGTG CATTTTACTCGGAGAGAGGCCATCAAGCAGATCGAGGTGCTGCAGCACGTGGCCACCAACCTGGGGCGC AGCCGTGCCTGGCTGTACCTGGCCCTCAACGAGAACTCCTTGGAGAGCTACCTGCGGTTGTTCCAGGAG AACCTGGGCCTGCTGCATAAGTACTACGTCAAGAATGCCCTGGTCTGCAGCCACGATCACCTGACGCTC TTCCTGACCTTGGTGTCCGGGCTAGAGTTCATTCGTTTCGAGCTGGATCTGGATGCCCCTTACCTAGAC CTGGCCCCCTACATGCCCGACTACTACAAACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGC TCGGTCCACGGCTCAGACAGTCTGTCCCTCAACTCTTTCAACTCCGTCACCTCCACCAACCTGGAGTGG GATGACAGTGCGATTGCCCCATCTAGTGAGGATTATGATTTTGGAGATGTGTTTCCAGCAGTGCCGTCT GTACCCAGCACAGACTGGGAAGATGGAGACCTCACAGACACGGTCAGTGGTCCCCGCTCCACAGCCTCC GACCTGACCAGCAGCAAGGCCTCCACCAGGAGCCCCACCCAGCGCCAGAACCCCTTCAACGAGGAGCCG GCAGAGACTGTGTCCTCCTCTGACACCACCCCCGTGCACACCACCTCTCAGGAGAAGGAGGAGGCCCAG GCCCTGGACCCGCCGGATGCCTGCACGGAGCTCGAGGTCATCAGGGTCACCAAGAAGAAGAAAATTGGC AAGAAGAAAAAGAGCAGATCAGATGAGGAGGCAAGTCCACTCCACCCCGCCTGCAGCCAGAAGAAATGT GCCAAGCAGGGGGACGGTGACAGCCGCAACGGCAGCCCAAGCCTTGGGCGGGACTCGCCAGACACTATG CTTGCCTCCCCCCAGGAGGAGGGAGAGGGGCCGAGCAGCACCACGGAGAGCAGCGAGCGCTCCGAGCCG GGCCTGCTGATCCCTGAGATGAAGGACACCTCCATGGAGCGCTTGGGGCAGCCCCTGAGCAAGGTTATC GACCAGCTCAACGGGCAGCTGGACCCCAGCACCTGGTGCTCCCGTGCTGAGCCCCCAGACCAGTCCTTT CGGACCGGCTCTCCCGGGGATGCCCCGGAGAGGCCGCCGCTTTGCGACTTTAGTGAGGGGCTTTCAGCC CCAATGGACTTCTACCGCTTTACCGTCGAGAGTCCAAGCACTGTTACATCAGGTGGCGGCCACCATGAC CCTGCAGGGCTTGGCCAACCGCTGCATGTTCCTAGTAGCCCTGAGGCTGCTGGCCAAGAAGAAGAGGGA GGAGGAGGAGAGGGACAGACGCCTCGGCCCCTAGAGGATACCACGAGGGAGGCTCAGGAGCTGGAGGCC CAGCTGTCCCTGGTCAGGGAGGGGCCTGTGTCTGAGCCAGAGCCTGGGACCCAGGAGGTTCTCTGCCAG CTCAAGCGAGACCAGCCCAGCCCGTGTCTGAGTAGCGCTGAGGATTCTGGGGTGGATGAGGGACAGGGG AGCCCTTCGGAGATGGTCCATTCCTCGGAGTTCAGAGTAGACAACAATCACCTGCTCCTGCTCATGATC CACGTGTTCCGAGAAAACGAAGAGCAGCTGTTCAAAATGATCCGGATGAGCACCGGGCACATGGAGGGC AACCTGCAGCTGCTGTACGTGCTGCTCACAGACTGCTATGTCTACCTGCTCCGGAAAGGGGCCACAGAG AAGCCATACCTGGTGGAAGAGGCCGTTTCTTACAATGAACTTGACTATGTGTCGGTTGGCCTTGACCAG CAGACGGTGAAGCTGGTGTGCACCAACCGCAGGAAGCAGTTTCTGCTGGACACGGCTGATGTGGCGCTG GCTGAGTTCTTTTTGGCTTCTTTGAAGTCAGCCATGATCAAAGGCTGTCGAGAACCTCCCTACCCCAGC ATCCTGACGGATGCCACCATGGAGAAGCTGGCACTGGCCAAATTTGTGGCCCAAGAATCGAAGTGTGAG GCATCTGCTGTCACCGTGCGCTTCTACGGCCTTGTGCACTGGGAGGACCCCACAGACGAGTCCCTGGGC CCCACGCCCTGCCACTGCTCACCCCCCGAGGGCACCATCACCAAAGAAGGCATGCTGCACTACAAGGCG GGCACCTCCTACCTGGGCAAGGAACACTGGAAGACGTGCTTCGTGGTGCTCAGCAACGGGATCCTCTAC CAGTACCCGGACCGCACCGACGTCATCCCTCTGCTCTCGGTGAACATGGGGGGGGAGCAGTGCGGTGGC TGCCGGAGAGCCAACACCACGGATCGGCCCCACGCCTTCCAGGTCATTCTCTCCGACCGGCCCTGCCTG GAGCTAAGTGCCGAGAGCGAGGCCGAGATGGCCGAGTGGATGCAGCATCTCTGCCAGGCTGTGTCCAAA GGGGTCATCCCCCAGGGCGTAGCTCCCAGCCCCTGCATACCCTGCTGCCTGGTCCTCACGGATGACCGC CTCTTTACGTGCCATGAGGATTGCCAGACCAGCTTCTTCCGCTCTTTGGGCACAGCCAAGCTGGGCGAC ATCAGCGCCGTCTCCACCGAGCCGGGCAAGGAGTACTGCGTCTTGGAGTTCTCCCAGGACAGCCAGCAG CTCCTCCCGCCCTGGGTCATCTACCTGAGCTGCACTTCTGAACTGGACCGATTGCTGTCTGCACTGAAC TCTGGGTGGAAAACCATCTATCAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAG AAATTCGAGGATGCCTTGAGCCTCATCCACAGCGCCTGGCAGCGGAGCGACAGTCTCTGCCGCGGCCGA GCCTCCCGAGACCCCTGGTGCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_015164 |
| Insert Size | 3060 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_015164.2 |
| RefSeq Size | 4138 bp |
| RefSeq ORF | 3060 bp |
| Locus ID | 23207 |
| UniProt ID | Q8IWE5 |
| Protein Families | Druggable Genome |
| MW | 112.8 kDa |
| Gene Summary | This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220299 | PLEKHM2 (Myc-DDK-tagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2) |
CNY 7,096.00 |
|
| RC220299L3 | Lenti ORF clone of Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), Myc-DDK-tagged |
CNY 12,640.00 |
|
| RC220299L4 | Lenti ORF clone of Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2), mGFP tagged |
CNY 12,640.00 |
|
| RG220299 | PLEKHM2 (tGFP-tagged) - Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2) |
CNY 11,780.00 |
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