NEDL2 (HECW2) (NM_020760) Human Untagged Clone
CAT#: SC304819
HECW2 (untagged)-Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2)
CNY 10,760.00
Product images
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | NDHSAL; NEDL2 |
Vector | pCMV6-XL6 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>OriGene sequence for NM_020760 edited
CAGACTGGGGCTGCAGATTTAGACGTAGACGTTTCCGAGGACGCGAGACTGCAGAGCTTT GTAGGCAGCCAATCCCAGAGAAGCAGACGGGATGGCTAGTTCAGCCCGGGAGCACCTGCT TTTTGTGAGGCGTCGAAATCCCCAGATGCGGTACACATTGAGCCCAGAGAACCTCCAGAG CCTTGCCGCCCAGAGCTCCATGCCAGAGAACATGACCCTGCAGCGGGCCAACAGCGACAC CGACCTGGTGACTTCTGAGAGCCGCTCCAGCTTAACTGCCAGCATGTACGAGTACACGCT GGGGCAAGCCCAGAACCTCATTATCTTCTGGGACATTAAAGAGGAGGTGGACCCCAGTGA TTGGATTGGACTTTATCATATAGATGAGAATTCTCCAGCCAACTTCTGGGATTCTAAGAA CAGGGGTGTGACTGGAACACAAAAAGGGCAAATTGTATGGAGAATTGAGCCTGGACCCTA TTTCATGGAACCGGAGATAAAAATCTGTTTTAAATATTACCACGGCATTAGTGGAGCCCT GCGAGCCACGACCCCCTGCATCACCGTGAAGAACCCAGCTGTGATGATGGGGGCAGAAGG CATGGAGGGAGGTGCTTCAGGAAACCTGCATTCTCGAAAACTTGTTAGCTTTACATTGTC AGATCTTAGGGCAGTTGGGCTAAAGAAAGGGATGTTCTTCAATCCTGACCCTTATCTTAA GATGTCAATTCAGCCAGGAAAGAAGAGCAGTTTCCCCACCTGTGCCCACCACGGGCAGGA GAGACGGTCTACTATCATCAGTAACACCACCAATCCAATTTGGCACCGAGAGAAATATTC CTTTTTTGCACTTCTTACTGATGTCTTAGAAATTGAAATTAAAGACAAATTTGCCAAGAG CCGTCCCATCATCAAGCGTTTTCTGGGGAAACTAACCATTCCAGTCCAGAGGCTGCTGGA GCGACAAGCCATCGGTGATCAAATGCTCAGCTACAACCTTGGCAGAAGGCTCCCAGCTGA CCACGTGAGTGGGTACCTCCAGTTTAAAGTGGAGGTTACGTCTTCTGTTCATGAAGATGC CTCTCCAGAAGCTGTTGGCACAATACTTGGAGTCAATTCTGTGAATGGAGACTTAGGTAG CCCTTCCGATGACGAGGACATGCCAGGGAGCCATCACGACAGCCAGGTGTGCTCTAATGG GCCAGTTTCTGAGGACAGTGCTGCCGATGGAACCCCCAAGCATTCATTCAGGACTAGCTC CACTCTGGAAATAGACACAGAGGAATTAACCTCTACGTCTTCAAGGACCTCACCTCCCAG AGGACGTCAGGATTCACTCAATGATTACTTAGATGCTATCGAACACAATGGCCACTCCAG GCCAGGGACAGCGACCTGCTCTGAGAGGTCCATGGGTGCCTCTCCGAAACTGAGGAGTAG TTTTCCCACTGACACAAGACTCAATGCCATGCTTCATATTGATTCAGATGAAGAAGATCA CGAGTTCCAGCAAGACCTGGGTTACCCATCTTCCTTGGAGGAGGAGGGAGGCCTGATCAT GTTTAGCAGGGCATCCAGAGCTGATGATGGAAGCCTGACATCTCAGACAAAGCTGGAGGA CAACCCTGTTGAGAATGAGGAAGCCTCCACACACGAAGCTGCTTCCTTTGAGGATAAGCC AGAAAATCTTCCAGAGCTTGCAGAGAGCTCCTTACCTGCAGGCCCAGCCCCAGAGGAAGG TGAAGGCGGCCCAGAGCCTCAACCCAGTGCTGACCAGGGCAGTGCTGAACTGTGTGGCTC TCAAGAGGTAGATCAGCCCACAAGTGGCGCAGACACAGGGACTTCCGATGCATCAGGAGG AAGCCGAAGAGCCGTCAGTGAGACCGAGTCTCTCGATCAGGGCTCTGAGCCTTCCCAGGT GTCCTCTGAAACAGAACCCAGTGATCCTGCCAGGACAGAGAGTGTGAGCGAAGCCAGCAC CAGGCCTGAGGGAGAGAGTGACCTGGAATGCGCTGACAGCTCCTGCAATGAGAGTGTGAC CACGCAGCTGTCCTCTGTGGACACACGGTGCTCCTCTCTTGAGAGCGCACGGTTTCCTGA AACCCCAGCCTTTTCTTCTCAGGAGGAGGAAGACGGAGCCTGTGCAGCAGAGCCCACCAG CAGTGGCCCTGCCGAAGGGTCGCAGGAATCCGTGTGCACTGCTGGTTCTTTACCTGTGGT ACAGGTGCCCAGTGGGGAGGATGAAGGGCCAGGGGCAGAATCGGCCACTGTACCTGACCA GGAGGAGCTGGGGGAGGTCTGGCAGCGGAGGGGGAGCCTGGAGGGAGCTGCAGCTGCTGC CGAGAGCCCACCGCAAGAAGAAGGCAGTGCTGGGGAGGCCCAAGGCACCTGTGAAGGGGC AACTGCCCAGGAGGAGGGCGCTACTGGAGGTTCTCAAGCCAACGGCCACCAGCCACTGCG ATCACTACCTTCAGTGCGCCAGGATGTTAGCCGGTACCAGAGGGTGGACGAGGCTCTCCC ACCAAACTGGGAGGCACGCATTGACAGCCACGGCAGGATCTTCTACGTGGATCACGTAAA CAGAACCACGACGTGGCAGCGACCGACAGCTCCCCCAGCCCCGCAGGTGCTGCAGAGATC TAACTCCATACAGCAAATGGAGCAGCTGAACCGGCGATATCAGAGTATCCGCAGAACCAT GACCAATGAGAGGCCTGAGGAAAATACCAATGCTATTGATGGGGCAGGGGAGGAAGCTGA CTTTCACCAAGCCAGTGCAGATTTCCGACGGGAGAACATCCTGCCTCACTCTACCTCCAG ATCCAGGATCACGTTGCTGTTACAGTCTCCCCCCGTGAAGTTCCTCATCAGCCCAGAGTT CTTCACCGTGCTGCATTCTAACCCTAGTGCCTACCGCATGTTTACAAACAACACGTGTTT GAAGCACATGATCACCAAAGTCCGGAGGGACACCCACCACTTTGAACGCTACCAGCATAA CCGCGACCTTGTGGGATTCCTCAACATGTTCGCGAACAAACAGCTAGAGCTGCCGCGGGG ATGGGAAATGAAACATGATCACCAGGGCAAGGCATTCTTTGTGGACCACAACTCCCGCAC CACCACTTTCATTGATCCCCGGCTCCCACTTCAGAGCAGTAGACCCACAAGTGCGCTGGT TCATCGGCAACACCTGACAAGGCAACGCAGCCACAGTGCGGGTGAGGTAGGAGAAGATTC TCGACATGCAGGACCACCAGTTCTTCCCAGGCCATCCAGTACATTCAATACAGTCAGTAG GCCACAGTACCAGGACATGGTTCCAGTGGCTTACAATGACAAGATTGTTGCATTTCTACG TCAACCCAATATCTTTGAAATTCTACAGGAGCGTCAACCTGATCTTACCAGGAATCACTC ACTCAGGGAGAAGATCCAATTTATCCGAACTGAAGGGACTCCAGGATTGGTGCGCCTTTC AAGCGATGCAGACCTTGTTATGTTGCTGAGCTTATTTGAAGAAGAGATAATGTCATATGT GCCTCCACATGCCTTACTCCACCCCAGCTACTGTCAGTCCCCACGTGGCTCTCCCGTGTC ATCTCCTCAGAACTCGCCAGGTACCCAGCGTGCCAATGCCCGGGCTCCAGCCCCTTACAA GCGGGATTTCGAAGCCAAACTGAGGAACTTTTACAGGAAGTTAGAGACTAAAGGATATGG ACAAGGCCCAGGGAAGTTAAAGTTAATTATCCGAAGAGATCACTTACTAGAAGATGCTTT TAATCAGATTATGGGCTACTCCAGAAAAGACCTGCAGAGAAATAAGCTATATGTCACCTT CGTTGGGGAGGAAGGGCTGGATTACAGTGGGCCTTCTAGAGAGTTTTTCTTCCTGGTATC CAGAGAACTCTTTAACCCATATTATGGCTTATTTGAATATTCAGCCAATGACACATACAC AGTACAAATAAGTCCTATGTCTGCTTTTGTAGACAATCACCATGAATGGTTCCGATTCAG TGGTAGGATCCTTGGTCTTGCACTAATACACCAGTATTTGTTGGATGCCTTCTTCACACG GCCCTTTTATAAGGCTCTTCTCAGAATTCTATGTGACCTGAGTGACCTAGAATACCTTGA TGAAGAGTTCCATCAGAGCCTGCAGTGGATGAAAGACAATGATATCCATGACATCCTAGA CCTCACGTTCACTGTGAACGAAGAAGTATTTGGGCAGATAACTGAACGAGAATTAAAGCC AGGGGGTGCCAATATCCCAGTTACAGAGAAGAACAAGAAGGAGTACATCGAGAGGATGGT GAAGTGGAGGATTGAGAGGGGTGTTGTACAGCAAACAGAGAGCTTAGTGCGTGGCTTCTA TGAGGTGGTGGATGCCAGGCTGGTATCTGTTTTTGATGCAAGAGAACTGGAATTGGTCAT CGCAGGCACAGCTGAAATAGACCTAAGTGATTGGAGAAACAACACAGAATATAGAGGAGG ATACCATGACAATCATATTGTAATTCGGTGGTTCTGGGCTGCAGTGGAAAGATTCAACAA TGAACAACGACTAAGGTTGTTACAGTTTGTTACAGGCACATCCAGCATTCCCTATGAAGG ATTTGCTTCACTCCGAGGGAGTAACGGCCCAAGAAGATTCTGTGTGGAGAAATGGGGGAA AATCACTGCTCTTCCCAGAGCGCATACATGTTTTAACCGTCTGGATCTGCCTCCCTACCC ATCCTTTTCCATGCTTTATGAAAAACTGTTGACAGCAGTTGAAGAAACCAGTACTTTTGG ACTTGAGTGACCTGGAAGCTGAATGCCCATCTCTGTGGACAGGCAGTTTCAGAAGCTGCC TTCTAGAAGAATGATTGAACATTGGAAGTTTCAAGAGGATGCTTCCTTTAGGATAAAGCT ACGTGCTGTTGTTTTCCAGGAACAAGTGCTCTGTCACATTTGGGGACTGGAGATGAGTCC TCTTGGAAGGATTTGGGTGAGCTTGATGCCCAGGGAACAACCCAACCGTCTTTCAATCAA CAGTTCTTGACTGCCAAACTTTTTCCATTTGTTATGTTCCAAGACAAAGATGAACCCATA CATGATCAGCTCCACGGTAATTTTTAGGGACTCAGGAGAATCTTGAAACTTACCCTTGAA CGTGGTTCAAGCCAAACTGGCAGCATTTGGCCCAATCTCCAAATTAGAGCAAGTTAAATA ATATAATAAAAGTAAATATATTTCCTGAAAGTACATTCATTTAAGCCCTAAGTTATAACA GAATATTCATTTCTTGCTTATGAGTGCCTGCATGGTGTGCACCATAGGTTTCCGCTTTCA TGGGACATGAGTGAAAATGAAACCAAGTCAATATGAGGTACCTTTACAGATTTGCAATAA GATGGTCTGTGACAATGTATATGCAAGTGGTATGTGTGTAATTATGGCTAAAGACAAACC ATTATTCAGTGAATTACTAATGACAGATTTTATGCTTTATAATGCATGAAAACAATTTTA AAATAACTAGCAATTAATCACAGCATATCAGGAAAAAGTACACAGTGAGTTCTGTTTATT TTTTGTAGGCTCATTATGTTTATGTTCTTTAAGATGTATATAAGAACCTACCTATCATGC TGTATGTATCACTCATTCCATTTTCATGTTCCATGCATACTCGGGCATCATGCTAATATG TATCCTTTTAAGCACTCTCAAGGAAACAAAAGGGCCTTTTATTTTTATAAAGGTAAAAAA AATTCCCCAAATATTTTGCACTGAATGTACCAAAGGTGAAGGGACATTACAATATGACTA ACAGCAACTCCATCACTTGAGAAGTATAATAGAAAATAGCTTCTAAATCAAACTTCCTTC ACAGTGCCGTGTCTACCACTACAAGGACTGTGCATCTAAGTAATAATTTTTTAAGATTCA CTATATGTGATAGTATGATATGCATTTATTTAAAATGCATTAGACTCTCTTCCATCCATC AAATACTTTACAGGATGGCATTTAATACAGATATTTCGTATTTCCCCCACTGCTTTTTAT TTGTACAGCATCATTAAACACTAAGCTCAGTTAAGGAGCCATCAGCAACACTGAAGAGAT CAGTAGTAAGAATTCCATTTTCCCTCATCAGTGAAGACACCACAAATTGAAACTCAGAAC TATATTTCTAAGCCTGCATTTTCACTGATGCATAATTTTCTTATTAATATTAAGAGACAG TTTTTCTATGGCATCTCCAAAACTGCATGACATCACTAGTCTTACTTCTGCTTAATTTTA TGAGAAGGTATTCTTCATTTTAATTGCTTTTGGGATTACTCCACATCTTTGTTTATTTCT TGACTAATCAGATTTTCAATAGAGTGAAGTTAAATTGGGGGTCATAAAAGCATTGGATTG ACATATGGTTTGCCAGCCTATGGGTTTACAGGCATTGCCCAAACATTTCTTTGAGATCTA TATTTATAAGCAGCCATGGAATTCCTATTATGGGATGTTGGCAATCTTACATTTTATAGA GGTCATATGCATAGTTTTCATAGGTGTTTTGTAAGAACTGATTGCTCTCCTGTGAGTTAA GCTATGTTTACTACTGGGACCCTCAAGAGGAATACCACTTATGTTACACTCCTGCACTAA AGGCACGTACTGCAGTGTGAAGAAATGTTCTGAAAAAGGGTTATAGAAATCTGGAAATAA GAAAGGAAGAGCTCTCTGTATTCTATAATTGGAAGAAAAAAAAAAAAAAA |
Restriction Sites | Please inquire |
ACCN | NM_020760 |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
Reference Data | |
RefSeq | NM_020760.1, NP_065811.1 |
RefSeq Size | 6926 bp |
RefSeq ORF | 4719 bp |
Locus ID | 57520 |
UniProt ID | Q9P2P5 |
Protein Families | Druggable Genome |
Gene Summary | This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC216544 | HECW2 (Myc-DDK-tagged)-Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) |
CNY 16,136.00 |
|
RC216544L1 | Lenti ORF clone of Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2), Myc-DDK-tagged |
CNY 18,536.00 |
|
RC216544L2 | Lenti ORF clone of Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2), mGFP tagged |
CNY 17,580.00 |
|
RC216544L3 | Lenti ORF clone of Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2), Myc-DDK-tagged |
CNY 17,580.00 |
|
RC216544L4 | Lenti ORF clone of Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2), mGFP tagged |
CNY 18,536.00 |
|
RG216544 | HECW2 (tGFP-tagged) - Human HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) |
CNY 17,736.00 |