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DKK1 (NM_012242) Human Untagged Clone
CAT＃: SC303946
DKK1 (untagged)-Human dickkopf homolog 1 (Xenopus laevis) (DKK1)
CNY 2,400.00
CNY 6,270.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DKK-1; SK |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_012242 edited
CCCTGCAGTCAGGACTCTGGGACCGCAGGGGGCTCCCGGACCCTGACTCTGCAGCCGAAC CGGCACGGTTTCGTGGGGACCCAGGCTTGCAAAGTGACGGTCATTTTCTCTTTCTTTCTC CCTCTTGAGTCCTTCTGAGATGATGGCTCTGGGCGCAGCGGGAGCTACCCGGGTCTTTGT CGCGATGGTAGCGGCGGCTCTCGGCGGCCACCCTCTGCTGGGAGTGAGCGCCACCTTGAA CTCGGTTCTCAATTCCAACGCTATCAAGAACCTGCCCCCACCGCTGGGCGGCGCTGCGGG GCACCCAGGCTCTGCAGTCAGCGCCGCGCCGGGAATCCTGTACCCGGGCGGGAATAAGTA CCAGACCATTGACAACTACCAGCCGTACCCGTGCGCAGAGGACGAGGAGTGCGGCACTGA TGAGTACTGCGCTAGTCCCACCCGCGGAGGGGACGCAGGCGTGCAAATCTGTCTCGCCTG CAGGAAGCGCCGAAAACGCTGCATGCGTCACGCTATGTGCTGCCCCGGGAATTACTGCAA AAATGGAATATGTGTGTCTTCTGATCAAAATCATTTCCGAGGAGAAATTGAGGAAACCAT CACTGAAAGCTTTGGTAATGATCATAGCACCTTGGATGGGTATTCCAGAAGAACCACCTT GTCTTCAAAAATGTATCACACCAAAGGACAAGAAGGTTCTGTTTGTCTCCGGTCATCAGA CTGTGCCTCAGGATTGTGTTGTGCTAGACACTTCTGGTCCAAGATCTGTAAACCTGTCCT GAAAGAAGGTCAAGTGTGTACCAAGCATAGGAGAAAAGGCTCTCATGGACTAGAAATATT CCAGCGTTGTTACTGTGGAGAAGGTCTGTCTTGCCGGATACAGAAAGATCACCATCAAGC CAGTAATTCTTCTAGGCTTCACACTTGTCAGAGACACTAAACCAGCTATCCAAATGCAGT GAACTCCTTTTATATAATAGATGCTATGAAAACCTTTTATGACCTTCATCAACTCAATCC TAAGGATATACAAGTTCTGTGGTTTCAGTTAAGCATTCCAATAACACCTTCCAAAAAAAA AAAAAAAAAAAAAA >OriGene 5' read for NM_012242 unedited
NAAGTCAACAATTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCCCTGCA GTCAGGACTCTGGGACCGCAGGGGCTCCCGGACCCTGACTCTGCAGCCGAACCGGCACGG TTTCGTGGGGACCCAGGCTTGCAAAGTGACGGTCATTTTCTCTTTCTTTCTCCCTCTTGA GTCCTTCTGAGATGATGGCTCTGGGCGCAGCGGGAGCTACCCGGGTCTTTGTCGCGATGG TAGCGGCGGCTCTCGGCGGCCACCCTCTGCTGGGAGTGAGCGCCACCTTGAACTCGGTTC TCAATTCCAACGCTATCAAGAACCTGCCCCCACCGCTGGGCGGCGCTGCGGGGCACCCAG GCTCTGCAGTCAGCGCCGCGCCGGGAATCCTGTACCCGGGCGGGAATAAGTACCAGACCA TTGACAACTACCAGCCGTACCCGTGCGCAGAGGACGAGGAGTGCGGCACTGATGAGTACT GCGCTAGTCCCACCCGCGGAGGGGACGCATGCGTGCAAATCTGTCTCGCCTGCAGGAAGC GCCGAANACGCTGCATGCGTCACGCTATGTGCTGCCCCGGGAATTACTGCAAAAATGGAA TATGTGTGTCTTCTGATCAAAATCATTTCCGAGGAGAAATTGANGAAACCATCACTGANA GCTTTGGTAATGATCATAGCACCTTGGATGGGTATTCCAGAAGAACCACCTTGTCTTCAA AAATGTATCACACCANAGGACAAGAAGGTTCTGTTTGTCTCCGGTCATCAGACTGTGCCT CAAGATTGTGTTGTGCTAGACACTTCTGGGTCAAGATCTGNTAACCTGTCCTGAAAGAAG GTCAAGTGTGTACCAAGCATAGGAGGAAAGGCTCTCATGGACTAGAAATATTCCAGCGTT GNTACTGTGG >OriGene 3' read for NM_012242 unedited
NACTTGTATATCCTTAGGATTGAGTTGATGAAGGTCATAAAAGGTTTTCATAGCATCTAT TATATAAAAGGAGTTCACTGCATTTGGATAGCTGGTTTAGTGTCTCTGACAAGTGTGAAG CCTAGAAGAATTACTGGCTTGATGGTGATCTTTCTGTATCCGGCAAGACAGACCTTCTCC ACAGTAACAACGCTGGAATATTTCTAGTCCATGAGAGCCTTTTCTCCTATGCTTGGTACA CACTTGACCTTCTTTCAGGACAGGTTTACAGATCTTGGACCAGAAGTGTCTAGCACAACA CAATCCTGAGGCACAGTCTGATGACCGGAGACAAACAGAACCTTCTTGTCCTTTGGTGTG ATACATTTTTGAAGACAAGGTGGTTCTTCTGGAATACCCATCCAAGGTGCTATGATCATT ACCAAAGCTTTCAGTGATGGTTTCCTCAATTTCTCCTCGGAAATGATTTTGATCAGAAGA CACACATATTCCATTTTTGCAGTAATTCCCGGGGCAGCACATAGCGTGACGCATGCAGCG TTTTCGGCGCTTCCTGCAGGCGAGACAGATTTGCACGCCTGCGTCCCCTCCGCGGGTGGG ACTAGCGCAGTACTCATCAGTGCCGCACTCCTCGTCCTCTGCGCACGGGTACGGCTGGTA GTTGTCAATGGTCTGGTACTTATTCCCGCCCGGGTACAGGATTCCCGGCGCGGCGCTGAC TGCAGAGCCTGGGTGCCCCGCAGCGCCGCCCCAGCGTGGGGGCAGGTTCTTGATAGCGTT GGAATTGAGAACCGAGTTCAAGGTGGCGCTCACTCCCAGCAGAGGGTGGCCGCCGAGAGC CGCCGCTACCATCGCGACAAAACCCGGGTAGCTCCCGCTGCGCCCAGAACATCA |
| Restriction Sites | Please inquire |
| ACCN | NM_012242 |
| Insert Size | 1103 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012242.2, NP_036374.1 |
| RefSeq Size | 1815 bp |
| RefSeq ORF | 801 bp |
| Locus ID | 22943 |
| UniProt ID | O94907 |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway |
| Protein Pathways | Wnt signaling pathway |
| Gene Summary | This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017] |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Bone Marrow Stromal Cells Create a Permissive Microenvironment for Myeloma Development: A New Stromal Role for Wnt Inhibitor Dkk1
,Jessica A. Fowler, Gregory R. Mundy, Seint T. Lwin, and Claire M. Edwards,
Cancer Res., May 2012; 72: 2183 - 2189.
[DKK1]
|
|
A Decrease in DKK1, a WNT Inhibitor, Contributes to Placental Lipid Accumulation in an Obesity-Prone Rat Model 1
,null,
Biology of Reproduction
,PubMed ID 22133691
[DKK1]
|
|
A Decrease in DKK1, a WNT Inhibitor, Contributes to Placental Lipid Accumulation in an Obesity-Prone Rat Model
,Rita S. Strakovsky and Yuan-Xiang Pan,
Biol Reprod, Mar 2012; 86: 81.
[DKK1]
|
|
SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC
,null,
Cell Death and Differentiation
,PubMed ID 22015605
[DKK1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200094 | DKK1 (Myc-DDK-tagged)-Human dickkopf homolog 1 (Xenopus laevis) (DKK1) |
CNY 2,400.00 |
|
| RC200094L1 | Lenti ORF clone of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200094L2 | Lenti ORF clone of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), mGFP tagged |
CNY 5,890.00 |
|
| RC200094L3 | Lenti ORF clone of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200094L4 | Lenti ORF clone of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), mGFP tagged |
CNY 4,800.00 |
|
| RG200094 | DKK1 (tGFP-tagged) - Human dickkopf homolog 1 (Xenopus laevis) (DKK1) |
CNY 4,000.00 |
