DKK1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, PEP-ELISA, WB
Recommend Dilution	ELISA: 1:128,000. WB: 1-3µg/ml.
Reactivity	Human, Rat, Dog, Pig, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence CDHHQASNSSRLHT, from the C Terminus of the protein sequence according to NP_036374.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	32296 Da
Gene Name	dickkopf WNT signaling pathway inhibitor 1
Database Link	NP_036374 Entrez Gene 293897 RatEntrez Gene 609600 DogEntrez Gene 22943 Human UniProt ID O94907
Background	This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq]
Synonyms	DKK-1; SK
Reference Data
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways	Wnt signaling pathway

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