IFIT3 (NM_001031683) Human Untagged Clone

CAT#: SC302530

IFIT3 (untagged)-Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2



  "NM_001031683" in other vectors (4)

CNY 3,656.00

CNY 7,220.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (4)
Anti-IFIT3 mouse monoclonal antibody, clone OTI1G1 (formerly 1G1)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_001031683 edited
GCTTGGAATCAGTAAGCTAAAAACAAAATCAACCGGGACCCCAGCTTTTCAGAACTGCAG
GGAAACAGCCATCATGAGTGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCT
GAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGA
TAGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTT
GTTGGCCTACATAAAACACCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCA
AGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCAC
TTGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTA
TGTAGATAAGGTGAAACAAACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTC
TGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAA
GGTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACT
GGCAATTGCGATGTACCATCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTT
GAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAA
ACTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAA
GTCTCCTTGCCAAACAGATGTCCTCCGCAGTGCAGCCAAATTTTACAGAAGAAAAGGTGA
CCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTA
CCTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGG
AGAATCTGAAGCTAGTGGAAATAAAGAGATGATTGAAGCACTAAAGCAATATGCTATGGA
CTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGC
TGAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGA
AAAGCAACAATCCCATCAGCGCTACTGCAACCTTCAGAAATATAATGGGAAGTCTGAAGA
CACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGA
AGAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAA
TTATTGGTATCTTCAAGGATTAATTCATAAGCAGAATGGAGATCTGCTGCAAGCAGCCAA
ATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTAT
TTTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAG
CTCCAGTCCCAGAGAGCTCCTCTCTAACTCAGAGCAACTGAACTGAGACAGAGGAGGAAA
ACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGG
GCCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTA
AAGAGTTGTTTTTTGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGG
CCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAAT
CCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGAAGGAAGAGGTTGCAGAG
AGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAA
AAAAAAAAAAAAAAA
Restriction Sites NotI-NotI     
ACCN NM_001031683
Insert Size 2000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001031683.1.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_001031683.1, NP_001026853.1
RefSeq Size 1999 bp
RefSeq ORF 1473 bp
Locus ID 3437
UniProt ID O14879
Gene Summary IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.[UniProtKB/Swiss-Prot Function]
Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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