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MRE11 (NM_005590) Human Untagged Clone
CAT＃: SC126932
MRE11A (untagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2
CNY 7,480.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ATLD; HNGS1; MRE11A; MRE11B |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC126932 sequence for NM_005590 edited (data generated by NextGen Sequencing)
ATGAGTACTGCAGATGCACTTGATGATGAAAACACATTTAAAATATTAGTTGCAACAGAT ATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTTGTAACACTC GATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGAT CTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTACATACCTGCCTCGAGTTATTAAGA AAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAAC TTTGGTTTTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATT CCAGTGTTTAGTATTCATGGCAATCATGACGATCCCACAGGGGCAGATGCACTTTGTGCC TTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAG AAGATAGACATTAGTCCGGTTTTGCTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGT TTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGTTTGTCAATAAAAAAGTAACAATG TTGAGACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGG AGTAAACATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTCATTGATCTT GTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTCCAACCAAAAATGAACAACAGCTG TTTTATATCTCACAACCTGGAAGCTCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTA AAGAAACATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCT CTTCACACAGTGCGGCAGTTTTTCATGGAGGATATTGTTCTAGCTAATCATCCAGACATT TTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTGGAGAAGATT GAAGAAATGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAG CCTCTTGTACGACTGCGAGTGGACTATAGTGGAGGTTTTGAACCTTTCAGTGTTCTTCGC TTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGG CATAGAGAACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAG CCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTGTAAAACAGTACTTTCAAACCGCA GAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAA TTTGTGGACAAGGAGGAGAAAGATGCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAA ACACAGCGATTTCTTAAAGAACGTCATATTGATGCCCTCGAAGACAAAATCGATGAGGAG GTACGTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGT GAGGCTATGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCTTCTGCCTTT AGTGCTGATGACCTTATGAGTATAGATTTAGCAGAACAGATGGCTAATGACTCTGATGAT AGCATCTCAGCAGCAACCAACAAAGGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGA GGGCAGAATTCAGCATCGAGAGGAGGGTCTCAANNNNNNNNNNNCTTTAAATCTACAAGA CAGCAGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGATTGAGGTAGATGAA TCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGC ACATCATCCAGCAAAATCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCA AGTGAGGATGATGATGATGATCCTTTTATGAACACTAGTTCTTTAAGAAGAAATAGAAGA TAA Clone variation with respect to NM_005590.3 1774 a=>n;1775 g=>n;1776 a=>n;1777 g=>n;1778 g=>n;1779 a=>n;1780 a=>n;1781 g=>n;1782 a=>n;1783 g=>n;1784 c=>n >OriGene 5' read for NM_005590 unedited
CTGACATTTGAGTACAGTACCCAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTT GACTGACCATAAAAATGAGTACTGCAGATGCACTTGATGATGAAAACACATTTAAAATAT TAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATA CGTTTGTAACACTCGATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTT TGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAACATTACATACCTGCC TCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTG ATCAGTCAGTCAACTTTGGTTTTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACC TCAACATTTCAATTCCAGTGTTTAGTATTCATGGNCATCATGACGATCCCACAGGGATGC ACTTTGTGCCTTGGACATTNTAAGTTGTGCTGGATTTGTNAATCACTTTGGACGTTCAAT GTCTGTGGAGAGATAGACATTAGTCCGGTTTTGCTTAAAAAGGAGCACAAGATTGCCTAT ATGGTTTAGGATCCATTCCGATGAAAGGCTCTATCGATGTTTGTCATAAAAAGTACATGT TGAGACAAGGAGAGAGACTCTGGGGTACTTATTGTGTTCTCAGACAGAGTACTTGGAGCC TACCTCTTCAACATTTTGGAGCTCTTGATCTTGAATTGGGCCTGACTGATGAAAAACTCA CAAAGACACCCTGTTTTTCTCAACTGAAGCAGGGTCTCTCTCCCGG >OriGene 3' read for NM_005590 unedited
TATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTAAGGAAAAAAAC TTTATTCCTTTTTTCCTAGGAACTTGTCAGGATACTTTAGTGACCATTCCCTCACTATAA CTCTCACCCAGACCCACCTAACTGATGCATGAGAAGAGCCACTAGCTGATGTGGCCCACA GCTCAGACTGAGCCAGCATGGCTTGCGCAGGGGTAGGTAGCACAGCATCATCCAGACACT GCCTCCCCTGGTAGCTTCCATTACATCATGGACAGCACTGCTCTTCCCTGACTTAACCTT CTGCTTTGTTCAAATACTAGAAATATTAGATTTCAAGTTCAATAAAGATGTGGGCAGATC TGCCTAAGAATATTTCACAGGACAACGCCTTCCACTGAGTTAATGCTACTTGCTCAAATA ACCCTTATGCTCAAGCCAGGTACAGAAAAAATATTTTTAAGAAAGTCAATACAATGTTAT ATTGCAAGTTCTGACTTACGCCTCTTCAAACGTGCTATATGAGGCAGCCACTAACCAAGT GTCTGTCTCTTATAATTNGACACATTCCAGGATGACTATTCTTAATGGTCATGAGTATCA CTGAGTCAAGGCTCTGCCTCCTACCTATAAAGAAATGTCGGGCCCACTGTACCTCCGAAG ACGTATAACTCCCCACTTATAAGTATCGCTGGTCGCCCACCACCCCCAGAAGGAATAACC CTCAGGGCCTCTTTTCCCCGAGGGATCATATCGAATGGGGTTATTTAACCTTACCTCTGA AGCAGGCCCATTCCTCATCTCTCCCCGCAAACACGGTTGGACTGCACCTTTTACATGGGC CTTTACGAATTCTCGACCTCGCCCTCTCCGAATGTCTCTCGGGCACCCCCAGGGAATCAT ACCTGCTCACGCGCAACCTTGCTTTGCTTTCGCCTCCCCCTCCCTATCTCTCTCCAGGGG TCACGCCCCCCCTCTTAATA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005590 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005590.3, NP_005581.2 |
| RefSeq Size | 5164 bp |
| RefSeq ORF | 2043 bp |
| Locus ID | 4361 |
| UniProt ID | P49959 |
| Domains | Metallophos, Mre11_DNA_bind |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Homologous recombination, Non-homologous end-joining |
| Gene Summary | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform 2 lacks an internal segment, compared to isoform 1. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213729 | MRE11A (Myc-DDK-tagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 7,968.00 |
|
| RC213729L1 | Lenti-ORF clone of MRE11A (Myc-DDK-tagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 10,368.00 |
|
| RC213729L2 | Lenti-ORF clone of MRE11A (mGFP-tagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 9,120.00 |
|
| RC213729L3 | Lenti-ORF clone of MRE11A (Myc-DDK-tagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 9,120.00 |
|
| RC213729L4 | Lenti-ORF clone of MRE11A (mGFP-tagged)-Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 9,120.00 |
|
| RG213729 | MRE11A (tGFP-tagged) - Human MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2 |
CNY 7,980.00 |
