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ADAR1 (ADAR) (NM_001111) Human Untagged Clone
CAT＃: SC119438
ADAR (untagged)-Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1
CNY 12,816.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119438 sequence for NM_001111 edited (data generated by NextGen Sequencing)
ATGAATCCGCGGCAGGGGTATTCCCTCAGCGGATACTACACCCATCCATTTCAAGGCTAT GAGCACAGACAGCTCAGATACCAGCAGCCTGGGCCAGGATCTTCCCCCAGTAGTTTCCTG CTTAAGCAAATAGAATTTCTCAAGGGGCAGCTCCCAGAAGCACCGGTGATTGGAAAGCAG ACACCGTCACTGCCACCTTCCCTCCCAGGACTCCGGCCAAGGTTTCCAGTACTACTTGCC TCCAGTACCAGAGGCAGGCAAGTGGACATCAGGGGTGTCCCCAGGGGCGTGCATCTCGGA AGTCAGGGGCTCCAGAGAGGGTTCCAGCATCCTTCACCACGTGGCAGGAGTCTGCCACAG AGAGGTGTTGATTGCCTTTCCTCACATTTCCAGGAACTGAGTATCTACCAAGATCAGGAA CAAAGGATCTTAAAGTTCCTGGAAGAGCTTGGGGAAGGGAAGGCCACCACAGCACATGAT CTGTCTGGGAAACTTGGGACTCCGAAGAAAGAAATCAATCGAGTTTTATACTCCCTGGCA AAGAAGGGCAAGCTACAGAAAGAGGCAGGAACACCCCCTTTGTGGAAAATCGCGGTCTCC ACTCAGGCTTGGAACCAGCACAGCGGAGTGGTAAGACCAGACGGTCATAGCCAAGGAGCC CCAAACTCAGACCCGAGTTTGGAACCGGAAGACAGAAACTCCACATCTGTCTCAGAAGAT CTTCTTGAGCCTTTTATTGCAGTCTCAGCTCAGGCTTGGAACCAGCACAGCGGAGTGGTA AGACCAGACAGTCATAGCCAAGGATCCCCAAACTCAGACCCAGGTTTGGAACCTGAAGAC AGCAACTCCACATCTGCCTTGGAAGATCCTCTTGAGTTTTTAGACATGGCCGAGATCAAG GAGAAAATCTGCGACTATCTCTTCAATGTGTCTGACTCCTCTGCCCTGAATTTGGCTAAA AATATTGGCCTTACCAAGGCCCGAGATATAAATGCTGTGCTAATTGACATGGAAAGGCAG GGGGATGTCTATAGACAAGGGACAACCCCTCCCATATGGCATTTGACAGACAAGAAGCGA GAGAGGATGCAAATCAAGAGAAATACGAACAGTGTTCCTGAAACCGCTCCAGCTGCAATC CCTGAGACCARAAGAAACGCAGAGTTCCTCACCTGTAATATACCCACATCAAATGCCTCA AATAACATGGTAACCACAGAAAAAGTGGAGAATGGGCAGGAACCTGTCATAAAGTTAGAA AACAGGCAAGAGGCCAGACCAGAACCAGCAAGACTGAAACCACCTGTTCATTACAATGGC CCCTCAAAAGCAGGGTATGTTGACTTTGAAAATGGCCAGTGGGCCACAGATGACATCCCA GATGACTTGAATAGTATCCGCGCAGCACCAGGTGAGTTTCGAGCCATCATGGAGATGCCC TCCTTCTACAGTCATGGCTTGCCACGGTGTTCACCCTACAAGAAACTGACAGAGTGCCAG CTGAAGAACCCCATCAGCGGGCTGTTAGAATATGCCCAGTTCGCTAGTCAAACCTGTGAG TTCAACATGATAGAGCAGAGTGGACCACCCCATGAACCTCGATTTAAATTCCAGGTTGTC ATCAATGGCCGAGAGTTTCCCCCAGCTGAAGCTGGAAGCAAGAAAGTGGCCAAGCAGGAT GCAGCTATGAAAGCCATGACAATTCTGCTAGAGGAAGCCAAAGCCAAGGACAGTGGAAAA TCAGAAGAATCATCCCACTATTCCACAGAGAAAGAATCAGAGAAGACTGCAGAGTCCCAG ACCCCCACCCCTTCAGCCACATCCTTCTTTTCTGGGAAGAGCCCCGTCACCACACTGCTT GAGTGTATGCACAAATTGGGGAACTCCTGCGAATTCCGTCTCCTGTCCAAAGAAGGCCCT GCCCATGAACCCAAGTTCCAATACTGTGTTGCAGTGGGAGCCCAAACTTTCCCCAGTGTG AGTGCTCCCAGCAAGAAAGTGGCAAAGCAGATGGCCGCAGAGGAAGCCATGAAGGCCCTG CATGGGGAGGCGACCAACTCCATGGCTTCTGATAACCAGCCTGAAGGTATGATCTCAGAG TCACTTGATAACTTGGAATCCATGATGCCCAACAAGGTCAGGAAGATTGGCGAGCTCGTG AGATACCTGAACACCAACCCTGTGGGTGGCCTTTTGGAGTACGCCCGCTCCCATGGCTTT GCTGCTGAATTCAAGTTGGTCGACCAGTCCGGACCTCCTCACGAGCCCAAGTTCGTTTAC CAAGCAAAAGTTGGGGGTCGCTGGTTCCCAGCCGTCTGCGCACACAGCAAGAAGCAAGGC AAGCAGGAAGCAGCAGATGCGGCTCTCCGTGTCTTGATTGGGGAGAACGAGAAGGCAGAA CGCATGGGTTTCACAGAGGTAACCCCAGTGACAGGGGCCAGTCTCAGAAGAACTATGCTC CTCCTCTCAAGGTCCCCAGAAGCACAGCCAAAGACACTCCCTCTCACTGGCAGCACCTTC CATGACCAGATAGCCATGCTGAGCCACCGGTGCTTCAACACTCTGACTAACAGCTTCCAG CCCTCCTTGCTCGGCCGCAAGATTCTGGCCGCCATCATTATGAAAAAAGACTCTGAGGAC ATGGGTGTCGTCGTCAGCTTGGGAACAGGGAATCGCTGTGTGAAAGGAGATTCTCTCAGC CTAAAAGGAGAAACTGTCAATGACTGCCATGCAGAAATAATCTCCCGGAGAGGCTTCATC AGGTTTCTCTACAGTGAGTTAATGAAATACAACTCCCAGACTGCGAAGGATAGTATATTT GAACCTGCTAAGGGAGGAGAAAAGCTCCAAATAAAAAAGACTGTGTCATTCCATCTGTAT ATCAGCACTGCTCCGTGTGGAGATGGCGCCCTCTTTGACAAGTCCTGCAGCGACCGTGCT ATGGAAAGCACAGAATCCCGCCACTACCCTGTCTTCGAGAATCCCAAACAAGGAAAGCTC CGCACCAAGGTGGAGAACGGAGAAGGCACAATCCCTGTGGAATCCAGTGACATTGTGCCT ACGTGGGATGGCATTCGGCTCGGGGAGAGACTCCGTACCATGTCCTGTAGTGACAAAATC CTACGCTGGAACGTGCTGGGCCTGCAAGGGGCACTGTTGACCCACTTCCTGCAGCCCATT TATCTCAAATCTGTCACATTGGGTTACCTTTTCAGCCAAGGGCATCTGACCCGTGCTATT TGCTGTCGTGTGACAAGAGATGGGAGTGCATTTGAGGATGGACTACGACATCCCTTTATT GTCAACCACCCCAAGGTTGGCAGAGTCAGCATATATGATTCCAAAAGGCAATCCGGGAAG ACTAAGGAGACAAGCGTCAACTGGTGTCTGGCTGATGGCTATGACCTGGAGATCCTGGAC GGTACCAGAGGCACTGTGGATGGGCCACGGAATGAATTGTCCCGGGTCTCCAAAAAGAAC ATTTTTCTTCTATTTAAGAAGCTCTGCTCCTTCCGTTACCGCAGGGATCTACTGAGACTC TCCTATGGTGAGGCCAAGAAAGCTGCCCGTGACTACGAGACGGCCAAGAACTACTTCAAA AAAGGCCTGAAGGATATGGGCTATGGGAACTGGATTAGCAAACCCCAGGAGGAAAAGAAC TTTTATCTCTGCCCAGTATAG Clone variation with respect to NM_001111.4 78 g=>a;1151 a=>r >OriGene 5' read for NM_001111 unedited
TAACCCCCGCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGC AGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCG AATTCGGCACGAGGCTTGGGCCCGGCGCGCAGACCCGCGGAGTTTCCCGTGCCGACGCCC CGGGGCCACTTCCAGTGCGGAGTAGCGGAGGCGTGGGGGCCTCGAGGGGCTGGCGCGGCC CAGCGGTCGGGCCAGGGTCGTGCCGCCGGCGGGTCGGGCCGGGCAATGCCTCGCGGGCGC AATGAATCCGCGGCAGGGGTATTCCCTCAGCGGATACTACACCCATCCATTTCAAGGCTA TGAGCACAGACAGCTCAGATACCAGCAGCCTGGGCCAGGATCTTCCCCCAGTAGTTTCCT GCTTAAGCAAATAGAATTTCTCAAGGGGCAGCTCCCAGAAGCACCGGTGATTGGAAAGCA GACACCGTCACTGCCACCTTCCCTCCCAGGACTCCGGCCAAGGTTTCCAGTACTACTTGC CTCCAGTACCAGAGGCAGGNCAGTGGACATCAGGGGTGTCCCCAGGGGCGTGCATCTCGG AAGTCAGGGGCTCCAGAGAGGGTTNCAGCATCCTTCACCACGTGGCAGGAGTCTGCCCAG AGAGGTGTTGATTGCCTTTTCTCACATTNCCAGGACTGAGTATCTACAAGATCAGGACAN AGGATCCTTAAGTTCCTGGAANAGCCTGGGGAAAGGAAGGGCANCACCGCACATGATCTG TCTGGGAAACTTGGGACTCCGAGAAGAAGTCAATCGAGTTTATACTCCTGGCAAAGAAGG CAGCTCAGAAGAGGCAGAACCCCCTTGTGAAAAAACGGGCTCCCTCAGCTTGGACCCAGC GGGGTGGGTAAGACCAACGGCTAGCCAGGGCCCACTAACCCCCGTTTGGACCGGGAA >OriGene 3' read for NM_001111 unedited
GGTTCCACTATGNNACCGCGGCCGCAATCTAGNGATCGGTTTTTTTTTTTTTTTTTTCAA ATTCTTGTTTTTTTTTTATTTATGAGGAATGTATATTGTTAAGTCACTGTTATCAAGGGA CACATAAAAGCAGAATCATAAAACTGGACTGCAGCCATCATCACAGTACCCGAGTCTATG CTTGGGGGTCTTCCTCACTCTGCTCTTGGAGTCACAACCAAGACTCCAAAAAACCAACGA AGTCCCTTCAATGTGAGTAAAGGAAACAGCTTCAAGCACTGACAATTTTTACAAGTGATT ATTCAAGGAATGCACAGTAGCCACAGTTCAGACAAATCAACTACAAAAATCATTAAAAAG AAGAGTAGGGAGGGTCACTGCTTATTAAAAACAAAAGACTGGACAAAGAAAGTGAAGATA ACAGTGGGCAGAAGCTCTGCCTCCTCTGTCCTGTGTGACTCACAGGGGCATGGGGGCATG GGGGCCCAAGGATGTGCGATCTGACACGGCTCGTTTCCAACAGATGCGTGGAATTCAAGG ATGCCTCGCTCTCTTCCTACAACAGAAACTGAATACTACAGGCTTGCTAAATAAAATCTT GGGGGGGAAGGGGGGGTTCTGAACTTGTGAAAACCCGTGTTCCCCGTTAAAAAAAAGCAA CTGGCCCAAACTCTGCTGGAAAACTCATGCCCCAGATGGACCCAAAGGCCAAACACCCGA GGACTCAGCGGGGACAACCCTGTGCCCTAAAAAAAAAGGGGTGCCCCTCCTTCTTATGCG GAAAACCCAAAACCTTTTTGCCCGGAATTGGGTGCCCAAAATGTTTTATGTTGCCCCCCA TAAACCCAAGCCGGGGAGAGGGCTTTTTCACTTTTGGAAAAGGGGCCCTTTTCTACCATT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001111 |
| Insert Size | 7000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001111.3, NP_001102.2 |
| RefSeq Size | 6640 bp |
| RefSeq ORF | 3681 bp |
| Locus ID | 103 |
| UniProt ID | P55265 |
| Domains | z-alpha, DSRM, A_deamin |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytosolic DNA-sensing pathway |
| Gene Summary | This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] Transcript Variant: This variant (1) encodes isoform (a, also referred to as ADAR-a). |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas
,Yang, B;Hu, P;Lin, X;Han, W;Zhu, L;Tan, X;Ye, F;Wang, G;Wu, F;Yin, B;Bao, Z;Jiang, T;Yuan, J;Qiang, B;Peng, X;,
Cell. Mol. Life Sci.
,PubMed ID 26047657
[ADAR]
|
|
New non-coding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyper-edited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription
,Cao, S;Moss, W;O'Grady, T;Concha, M;Strong, MJ;Wang, X;Yu, Y;Baddoo, M;Zhang, K;Fewell, C;Lin, Z;Dong, Y;Flemington, EK;,
J. Virol.
,PubMed ID 25926645
[ADAR]
|
|
Five novel mutations in the ADAR1 gene associated with dyschromatosis symmetrica hereditaria
,Liu, Q;Wang, Z;Wu, Y;Cao, L;Tang, Q;Xing, X;Ma, H;Zhang, S;Luo, Y;,
BMC Med. Genet.
,PubMed ID 24950769
[ADAR]
|
|
F11R Expression upon Hypoxia Is Regulated by RNA Editing
,Ben-Zvi, M;Amariglio, N;Paret, G;Nevo-Caspi, Y;,
PLoS One. 2013 Oct 16;8(10):e77702
,PubMed ID 24147060
[ADAR]
|
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Resources
Other Versions
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| RC207522 | ADAR (Myc-DDK-tagged)-Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1 |
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| RC207522L1 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, Myc-DDK-tagged |
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| RC207522L2 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, mGFP tagged |
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| RC207522L3 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, Myc-DDK-tagged |
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| RC207522L4 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, mGFP tagged |
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| RG207522 | ADAR (tGFP-tagged) - Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1 |
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