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CDK7 (NM_001799) Human Untagged Clone
CAT＃: SC119024
CDK7 (untagged)-Human cyclin-dependent kinase 7 (CDK7)
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAK; CAK1; CDKN7; HCAK; MO15; p39MO15; STK1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_001799 edited
ATGGCTCTGGACGTGAAGTCTCGGGCAAAGCGTTATGAGAAGCTGGACTTCCTTGGGGAG GGACAGTTTGCCACCGTTTACAAGGCCAGAGATAAGAATACCAACCAAATTGTCGCCATT AAGAAAATCAAACTTGGACATAGATCAGAAGCTAAAGATGGTATAAATAGAACCGCCTTA AGAGAGATAAAATTATTACAGGAGCTAAGTCATCCAAATATAATTGGTCTCCTTGATGCT TTTGGACATAAATCTAATATTAGCCTTGTCTTTGATTTTATGGAAACTGATCTAGAGGTT ATAATAAAGGATAATAGTCTTGTGCTGACACCATCACACATCAAAGCCTACATGTTGATG ACTCTTCAAGGATTAGAATATTTACATCAACATTGGATCCTACATAGGGATCTGAAACCA AACAACTTGTTGCTAGATGAAAATGGAGTTCTAAAACTGGCAGATTTTGGCCTGGCCAAA TCTTTTGGGAGCCCCAATAGAGCTTATACACATCAGGTTGTAACCAGGTGGTATCGGGCC CCCGAGTTACTATTTGGAGCTAGGATGTATGGTGTAGGTGTGGACATGTGGGCTGTTGGC TGTATATTAGCAGAGTTACTTCTAAGGGTTCCTTTTTTGCCAGGAGATTCAGACCTTGAT CAGCTAACAAGAATATTTGAAACTTTGGGCACACCAACTGAGGAACAGTGGCCGGACATG TGTAGTCTTCCAGATTATGTGACATTTAAGAGTTTCCCTGGAATACCTTTGCATCACATC TTCAGTGCAGCAGGAGACGACTTACTAGATCTCATACAAGGCTTATTCTTATTTAATCCA TGTGCTCGAATTACGGCCACACAGGCACTGAAAATGAAGTATTTCAGTAATCGGCCAGGG CCAACACCTGGATGTCAGCTGCCAAGACCAAACTGTCCAGTGGAAACCTTAAAGGAGCAA TCAAATCCAGCTTTGGCAATAAAAAGGAAAAGAACAGAGGCCTTAGAACAAGGAGGATTG CCCAAGAAACTAATTTTTTAA >OriGene 5' read for NM_001799 unedited
NGTCGGAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGGGTAGCTTT AAATTCGTGTTGTCCTGGGAGCTCGCCCTTTTCGGCTGGAGTCGGGCTTTACGGCGCCGG ATGGCTCTGGACGTGAAGTCTCGGGCAAAGCGTTATGAGAAGCTGGACTTCCTTGGGGAG GGACAGTTTGCCACCGTTTACAAGGCCAGAGATAAGAATACCAACCAAATTGTCGCCATT AAGAAAATCAAACTTGGACATAGATCAGAAGCTAAAGATGGTATAAATAGAACCGCCTTA AGAGAGATAAAATTATTACAGGAGCTAAGTCATCCAAATATAATTGGTCTCCTTGATGCT TTTGGACATAAATCTAATATTAGCCTTGTCTTTGATTTTATGGAAACTGATCTAGAGGTT ATAATAAAGGATAATAGTCTTGTGCTGACACCATCACACATCAAAGCCTACATGTTGATG ACTCTTCAAGGATTAGAATATTTACATCAACATTGGATCCTACATAGGGATCTGAAACCA AACAACTTGTTGCTAGATGAAAATGGAGTTCTAAAACTGGCAGATTTTGGCCTGGCCAAA TCTTTTGGGAGCCCCAATAGAGCTTATACACATCAGGTTGTAACCAGGTGGTATCGGGCC CCCGAGTTACTATTTGGAGCTAGGATGTATGGTGTANGTGTGGACATGTGGGCTGTTGGC TGTATATTAGCAGAGTTACTTCTAAGGGTTCCTTTTTTGCCAGNAGATTCAGACCTTGAT CAGCTAACAAGAATATTTGAAACTTTGNGCACACCAACTGAGNAACAGTGGCCGGACATG TGTAGTCTTCCAGAATATGTGACATTTAAGAGTTTCCCTGGATACTTNGCATCACATCTC AGTGCC >OriGene 3' read for NM_001799 unedited
GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAAATTTTTATTTTAAAATACAT TTAATAAAAATAACCCATAGTTTTACATATTTTACATGTGTAGAATATTTACAAACTCAC TTCTACAGCATTTACTTAATGTTTACTATTTTTCCATTATTTGCCTTTTTGGCTATTTCC CTCAGTAGTAAAATGTTGTCCAGTGTTCTCTTTAAAAAATTAGTTTCTTGGGCAATCCTC CTTGTTCTAAGGCCTCTGTTCTTTTCCTTTTTATTGCCAAAGCTGGATTTGATTGCTCCT TTAAGGTTTCCACTGGACAGTTTGGTCTTGGCAGCTGACATCCAGGTGTTGGCCCTGGCC GATTACTGAAATACTTCATTTTCAGTGCCTGTGTGGCCGTAATTCGAGCACATGGATTAA ATAAGAATAAGCCTTGTATGAGATCTAGTAAGTCGTCTCCTGCTGCACTGAAGATGTGAT GCAAAGGTATTCCAGGGAAACTCTTAAATGTCACATAATCTGGAAGACTACACATGTCCG GCCACTGTTCCTCAGTTGGTGTGCCCAAAGTTTCAAATATTCTTGTTAGCTGATCAAGGT CTGAATCTCCTGGCAAAAAAGGAACCCTTAGAAGTAACTCTGCTAATATACAGCCAACAG CCCACATGTCCACACCTACACCATACATCCTAGCTCCAAATAGTAACTCGGNGGCCCGAT ACCACCTGGTTACAACCTGATGTGTATAAGCTCTATTGGGGCTCCCAAAAGAATTGGCCA GGCCAAAATCTGCCAGTTTTAGAACTCCATTCTCATCTAGCAACCCAGTGTTTGGNTTCA GATCCCTATGTAGATCCAAGTTGATGTAAATATCTAATCCTTGAGAGTCTCACCTGTTAG CTTGAGGGTGATGGGTCACCACAGAAATATCCTTATTAAACCCTTAACAGTTCCATAAAA CAAGCAAGCTAATTAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001799 |
| Insert Size | 1280 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001799.2, NP_001790.1 |
| RefSeq Size | 1427 bp |
| RefSeq ORF | 1041 bp |
| Locus ID | 1022 |
| UniProt ID | P50613 |
| Domains | pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Cell cycle, Nucleotide excision repair |
| Gene Summary | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Cross-talk Among RNA Polymerase II Kinases Modulates C-terminal Domain Phosphorylation
,Ballachanda N. Devaiah and Dinah S. Singer,
J. Biol. Chem., Nov 2012; 287: 38755 - 38766.
[CDK7]
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|
CDKN1C Negatively Regulates RNA Polymerase II C-terminal Domain Phosphorylation in an E2F1-dependent Manner
,Yihong Ma, Lu Chen, Gabriela M. Wright, Smitha R. Pillai, Srikumar P. Chellappan, and W. Douglas Cress,
J. Biol. Chem., Mar 2010; 285: 9813 - 9822
[CDK7]
|
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Resources
Other Versions
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| RC202736L3 | Lenti ORF clone of Human cyclin-dependent kinase 7 (CDK7), Myc-DDK-tagged |
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| RC202736L4 | Lenti ORF clone of Human cyclin-dependent kinase 7 (CDK7), mGFP tagged |
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| SC323465 | CDK7 (untagged)-Kinase deficient mutant (K41M) of Human cyclin-dependent kinase 7 (CDK7) |
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