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PPP4C (NM_002720) Human Untagged Clone
CAT＃: SC118440
PPP4C (untagged)-Human protein phosphatase 4, catalytic subunit (PPP4C)
CNY 2,400.00
CNY 2,950.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | PP-X; PP4; PP4C; PPH3; PPP4; PPX |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118440 sequence for NM_002720 edited (data generated by NextGen Sequencing)
ATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGAGCTCATC AAGGAGAGCGAAGTCAAGGCCCTGTGCGCTAAGGCCAGAGAGATCTTGGTAGAGGAGAGC AACGTGCAGAGGGTGGACTCGCCAGTCACAGTGTGCGGCGACATCCATGGACAATTCTAT GACCTCAAAGAGCTGTTCAGAGTAGGTGGCGACGTCCCTGAGACCAACTACCTCTTCATG GGGGACTTTGTGGACCGTGGCTTCTATAGCGTCGAAACGTTCCTCCTGCTGCTGGCACTT AAGGTTCGCTATCCTGATCGCATCACACTGATCCGGGGCAACCATGAGAGTCGCCAGATC ACGCAGGTCTATGGCTTCTACGATGAGTGCCTGCGCAAGTACGGCTCGGTGACTGTGTGG CGCTACTGCACTGAGATCTTTGACTACCTCAGCCTGTCAGCCATCATCGATGGCAAGATC TTCTGCGTGCACGGGGGCCTCTCCCCCTCCATCCAGACCCTGGATCAGATTCGGACAATC GACCGAAAGCAAGAGGTGCCTCATGATGGGCCCATGTGTGACCTCCTCTGGTCTGACCCA GAAGACACCACAGGCTGGGGCGTGAGCCCCCGAGGAGCCGGCTACCTATTTGGCAGTGAC GTGGTGGCCCAGTTCAACGCAGCCAATGACATTGACATGATCTGCCGTGCCCACCAACTG GTGATGGAAGGTTACAAGTGGCACTTCAATGAGACGGTGCTCACTGTGTGGTCGGCACCC AACTACTGCTACCGCTGTGGGAATGTGGCAGCCATCTTGGAGCTGGACGAGCATCTCCAG AAAGATTTCATCATCTTTGAGGCTGCTCCCCAAGAGACACGGGGCATCCCCTCCAAGAAG CCCGTGGCCGACTACTTCCTGTGA Clone variation with respect to NM_002720.1 >OriGene 5' read for NM_002720 unedited
NATTATGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCGGCGGCGGCG GTCGAAAGCGGAGTGAAAGAGGGAGGCAGGGAGCCGGAGAGCCGGAACCGGAGTCGCAGC GGCGGAGACCCCTGTGCGGTGCGGAGGGGGCGGCGGCCCCGACTCTGACCCGCGCCGGGG GTGGGCCATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGA GCTCATCAAGGAGAGCGAAGTCAAGGCCCTGTGCGCTAAGGCCAGAGAGATCTTGGTAGA GGAGAGCAACGTGCAGAGGGTGGACTCGCCAGTCACAGTGTGCGGCGACATCCATGGACA ATTCTATGACCTCAAAGAGCTGTTCAGAGTAGGTGGCGACGTCCCTGAGACCAACTACCT CTTCATGGGGGACTTTGTGGACCGTGGCTTCTATAGCGTCGAAACGTTCCTCCTGCTGCT GGCACTTAAGGTTCGCTATCCTGATCGCATCACACTGATCCGGGGCAACCATGAGAGTCG CCAGATCACGCAGGTCTATGGCTTCTACGATGAGTGCCTGCGCAAGTACGGCTCGGTGAC TGTGTGGCGCTACTGCACTGAGATCTTTGACTACCTCAGCCTGTCAGCCATCATCGATGG CAAGATCTTCTGCGTGCACGGNGGCCTCTCCCCCTCCATCCAGACCCTGGATCAGATTCG GACAATCGACCGANAGCAAGAAGTGCCTCATGATGGGCCCATGTGTGACCTCCTCTGGTC TGACCCAGAAGACACCACAGGCTGGNGCGTGAGCCCNNCGAGAGCCGCTACCTANTTGGC AGTGACGTGGTGGCCCAGNTCAACGCAGCCAATGACATTGACATGATCTGCCGTGCCCAC CACTGGTGATGGNAGGTTACAGTGCACTTCATGAGACGTGCTCACTGGTGGTCGCACCAC TACGCTACGCTGTGGAT >OriGene 3' read for NM_002720 unedited
NTTTTCATTAGCTTGCACCGTCGGCCGCATNCTACGAGCGAGTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAACCCATTTTTCTTTTTTTATTAAAA TTTTTTCATTTTTTTTCTCAAAATTTTTATCTAAAACCAACCCGAAAAAAGAAGGAAAAA AAAAAAAAAAAATTATTGGAAAACTTCATGGTTCAAGGGGGGAAAGAGGAGGAGGAACAT GGAGCTAGGTCTCCAGGCCTTTCCAAAAAAGTCCTCACCCTCAAAGCCCCCTTTTGGGGG ACAGCAAAGCCAGGACAGCCCCCCCCCACCCCCAGCCTCCGTTTGAGGAAAAGGGCAAAC CCCCAGGGGGGCAAGGGCCAAAAGGGTTGGAGGGGGCAGGGCCCGGGCGGGGTCACAGGA AATAATCGGCCCCGGCCTTTTTGGAGGGGATGCCCCGTGTCTTTTGGGGAGCCCCCTCAA AGAGGAGGAAATTTTTTTGGAAAGGCTCGCCCCGCTCCAAAAGGGCTGCCACATTCCCAC AGGGGAAACAGAAGTTGGGTGCCCACCACCCAGTGAGCACCGTTTCATTGAAGGGCCCCT TGTACCCTTCCATCCCCAGTTGGGGGGCCCGGAAAACCATGCCAAGGCCATTGGCTGCGT TAAACTGGCCCACCACGCCCCTGCCAAATAGGTACCCGGCTCCTCGGGGGCTCACCCCCC CCCCTGGGGTGCCTTTTGGGCCACACCCAAGGAGGCCCCCCCTGGCCCCATCATGAGGCC ACCTTTGCTTTCGGGCGATTGCCCCAATCTCACACACGGTCTGGATGGAGGGGGAAAAGG CCCCTCTGGCACCCCAAAAAACTTTGCCATCCAAAAAGGCTTACACGCCCCCAGGACCCA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002720 |
| Insert Size | 1550 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002720.1, NP_002711.1 |
| RefSeq Size | 1429 bp |
| RefSeq ORF | 924 bp |
| Locus ID | 5531 |
| UniProt ID | P60510 |
| Domains | Metallophos, PP2Ac |
| Protein Families | Druggable Genome, Phosphatase |
| Gene Summary | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200538 | PPP4C (Myc-DDK-tagged)-Human protein phosphatase 4, catalytic subunit (PPP4C) |
CNY 4,465.00 |
|
| RC200538L1 | Lenti ORF clone of Human protein phosphatase 4, catalytic subunit (PPP4C), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200538L2 | Lenti ORF clone of Human protein phosphatase 4, catalytic subunit (PPP4C), mGFP tagged |
CNY 5,890.00 |
|
| RC200538L3 | Lenti ORF clone of Human protein phosphatase 4, catalytic subunit (PPP4C), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200538L4 | Lenti ORF clone of Human protein phosphatase 4, catalytic subunit (PPP4C), mGFP tagged |
CNY 4,800.00 |
|
| RG200538 | PPP4C (tGFP-tagged) - Human protein phosphatase 4, catalytic subunit (PPP4C) |
CNY 4,000.00 |
|
| SC320616 | PPP4C (untagged)-Human protein phosphatase 4, catalytic subunit (PPP4C) |
CNY 2,400.00 |
