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PPP4C (NM_002720) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC200538L4V
- LentiORF®
-
Lenti ORF particles, PPP4C (mGFP-tagged) - Human protein phosphatase 4, catalytic subunit (PPP4C), 200ul, >10^7 TU/mL
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CNY 9,120.00
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CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | PPP4C (NM_002720) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | PP-X; PP4; PP4C; PPH3; PPP4; PPX |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_002720 |
| ORF Size | 921 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200538).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_002720.1 |
| RefSeq Size | 1429 bp |
| RefSeq ORF | 924 bp |
| Locus ID | 5531 |
| Domains | Metallophos, PP2Ac |
| Protein Families | Druggable Genome, Phosphatase |
| MW | 35.1 kDa |
| Gene Summary | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.[UniProtKB/Swiss-Prot Function] |
Documents
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| FAQs |
| SDS |
