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POT1 (NM_015450) Human Untagged Clone
CAT＃: SC112647
POT1 (untagged)-Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1
CNY 4,728.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CMM10; GLM9; HPOT1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC112647 sequence for NM_015450 edited (data generated by NextGen Sequencing)
ATGTCTTTGGTTCCAGCAACAAATTATATATATACACCCCTGAATCAACTTAAGGGTGGT ACAATTGTCAATGTCTATGGTGTTGTGAAGTTCTTTAAGCCCCCATATCTAAGCAAAGGA ACTGATTATTGCTCAGTTGTAACTATTGTGGACCAGACAAATGTAAAACTAACTTGCCTG CTCTTTAGTGGAAACTATGAAGCCCTTCCAATAATTTATAAAAATGGAGATATTGTTCGC TTTCACAGGCTGAAGATTCAAGTATATAAAAAGGAGACTCAGGGTATCACCAGCTCTGGC TTTGCATCTTTGACGTTTGAGGGAACTTTGGGAGCCCCTATCATACCTCGCACTTCAAGC AAGTATTTTAACTTCACTACTGAGGACCACAAAATGGTAGAAGCCTTACGTGTTTGGGCA TCTACTCATATGTCACCGTCTTGGACATTACTAAAATTGTGTGATGTTCAGCCAATGCAG TATTTTGACCTGACTTGTCAGCTCTTGGGCAAAGCAGAAGTGGACGGAGCATCATTTCTT CTAAAGGTATGGGATGGCACCAGGACACCATTTCCATCTTGGAGAGTCTTAATACAAGAC CTTGTTCTTGAAGGTGATTTAAGTCACATCCATCGGCTACAAAATCTGACAATAGACATT TTAGTCTACGATAACCATGTTCATGTGGCAAGATCTCTGAAGGTTGGAAGCTTTCTTAGA ATCTATAGCCTTCATACCAAACTTCAATCAATGAATTCAGAGAATCAGACAATGTTAAGT TTAGAGTTTCATCTTCATGGAGGTACCAGTTACGGTCGGGGAATCAGGGTCTTGCCAGAA AGTAACTCTGATGTGGATCAACTGAAAAAGGATTTAGAATCTGCAAATTTGACAGCCAAT CAGCATTCAGATGTTATCTGTCAATCAGAACCTGACGACAGCTTTCCAAGCTCTGGATCA GTATCATTATACGAGGTAGAAAGATGTCAACAGCTATCTGCTACAATACTTACAGATCAT CAGTATTTGGAGAGGACACCACTATGTGCCATTTTGAAACAAAAAGCTCCTCAACAATAC CGCATCCGAGCAAAATTGAGGTCATATAAGCCCAGAAGACTATTTCAGTCTGTTAAACTT CATTGCCCTAAATGTCATTTGCTGCAAGAAGTTCCACATGAGGGCGATTTGGATATAATT TTTCAGGATGGTGCAACTAAAACCCCAGATGTCAAGCTACAAAATACATCATTATATGAT TCAAAAATCTGGACCACTAAAAATCAAAAAGGACGAAAAGTAGCAGTTCATTTTGTGAAA AATAATGGTATTCTCCCGCTTTCAAATGAATGTCTACTTTTGATAGAAGGAGGTACACTC AGTGAAATTTGCAAACTCTCGAACAAGTTTAATAGTGTAATTCCTGTGAGATCTGGCCAC GAAGACCTGGAACTTTTGGACCTTTCAGCACCATTTCTTATACAAGGAACAATACATCAC TATGGATGTAAACAGTGTTCTAGTTTGAGATCCATACAAAATCTAAATTCCCTGGTTGAT AAAACATCGTGGATTCCTTCTTCTGTGGCAGAAGCACTGGGTATTGTACCCCTCCAATAT GTGTTTGTTATGACCTTTACACTTGATGATGGAACAGGAGTACTAGAAGCCTATCTCATG GATTCTGACAAATTCTTCCAGATTCCAGCATCAGAAGTTCTGATGGATGATGACCTTCAG AAAAGTGTGGATATGATCATGGATATGTTTTGTCCTCCAGGAATAAAAATTGATGCATAT CCGTGGTTGGAATGCTTCATCAAGTCATACAATGTCACAAATGGAACAGATAATCAAATT TGCTATCAGATTTTTGACACCACAGTTGCAGAAGATGTAATCTAA Clone variation with respect to NM_015450.2 >OriGene 5' read for NM_015450 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGCAAGTTGTCAGAT TCCCTAGTTGAATTTGCTTTGGACATCAGTGTGAAGCAGAACTGATATGCCACTTGAATT AATAAAGGAAGTCAATGGGGTGCCTGAAGTTCAGCCGCTGAGTAAATTACATAAAGTAGA TTTCGGATCCCTACAGCCAGGTTACAATTATAGCAAGAAATATATTCAGGGAAAACTTTC ACTTATCTCTTCTTTAACTTATCGTGGAAATAAAACAGCTGTTTTGCAGATTGGACTACA AGGACACCATTGCAGTGGCTAGATTTATTGTTTTTTTAGCTTCTTCATCTACAAGCAGAG ATGGTAAACCTTGCATATTTTTGAAAGCATTTGAAGACCTCAAATCAACTGTTTATGTTT ATGTCAAATCTTTAAGAGATTTTTCTACAGAATCAATGTCTTTGGTTCCAGCAACAAATT ATATATATACACCCCTGAATCAACTTAAGGGTGGTACAATTGTCAATGTCTATGGTGTTG TGAAGTTCTTTAAGCCCCCATATCTAAGCAAAGGAACTGATTATTGCTCAGTTGTAACTA TTGTGGACCAGACAAATGTAAAACTAACTTGCCTGCTCTTTAGTGGAAACTATGAAGCCC TTCCAATAATTTATAAAAATGGAGATATTGTTCGCTTTCACAGGCTGAAGATTAAGTATA TAAAAAGGAGACTCAGGNTATCACCAGCTCTGGCTTTGCATCTTTGACGTTTGAGGGAAC TTGGGNAGCCCTATCATACCTCGCACTTCAAGCAGTATTTTAACTTCACTACTGAGACAC ANATGTAGAAGCCTTACTGTTTGGGCACTACTATATGCACCGTCTGGACATACTAAATGT GGGATGTCACCAAGCGTTTTTGACTGC >OriGene 3' read for NM_015450 unedited
TCTATGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAACATTATA AATCTGACCACTTTTATTAGGTTGAGGTGAAATAGAGAAATCTCTACTATCCTGGAGAGA AACAAGCAATAAAACCATGTATTACAAGTTTAAAGAAATGAATTTATCCTAAAATCATCA GTATCAGCACCCCAACAAAGCAACTTTGCCATTTCTACTTAAAGTACACTGTAGCTTGAT CAGACACTTATCTCAGCAGTACTTGTTTAAGCAGGTCTCTTTGTACAAAAGCAAAACAGA AAGCAAAACAAAATCCATAGCCATTATTTACCTTGCACCCAGTAAAAGCCAAGAGATTTA AGGTAAGGACATTTTCTAATCCCATACCCATGCTAACATCATCAACATTGCTGATACAAA ACTCAGGTCAGGAAAAGAAGCTCAAACAGGGAAGGTGAGTGGCAACATTTTATGTATGCT AAATTGGATGGCAATATTAGATTACATCTTCTGCAACTGTGGTGTCAAAAATCTGATAGC AAATTTGATTATCTGTTCCATTTGTGACATTGTATGACTTGATGAAGCATTCCAACCACG GATATGCATCAATTTTTATTCCTGGAGGACAAAACATATCCATGATCATATCCACACTTT TCTGAAGGTCATCATCCATCAGAACTTCTGATGCTGGAATCTGGAAGAATTTGTCAGAAT CCATGAGATAGGCTTCTAGTACTCCTGTTCCATCATCAAGTGTAAGGTCATAACAACACA TATGGNAGGGGTACATACCCAGTGCTTCTGCCACAGAGAAGGATCCACCGATGTTTATCA CCANGGAATTTAGATTTGNATNGATCTCAAACTAAACACTGNTACATCCTAGGGATGNAT TGGTCCTTGGATAAAAATGGGGCTGAAAGGTNCAAAGGTTCAGTNCTTCTGGGCCGATCT TCACGGATACACTTATAAACTTGTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_015450 |
| Insert Size | 2930 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015450.1, NP_056265.1 |
| RefSeq Size | 2631 bp |
| RefSeq ORF | 1905 bp |
| Locus ID | 25913 |
| UniProt ID | Q9NUX5 |
| Gene Summary | This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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POT1 loss-of-function variants predispose to familial melanoma
,Robles-Espinoza, CD;Harland, M;Ramsay, AJ;Aoude, LG;Quesada, V;Ding, Z;Pooley, KA;Pritchard, AL;Tiffen, JC;Petljak, M;Palmer, JM;Symmons, J;Johansson, P;Stark, MS;Gartside, MG;Snowden, H;Montgomery, GW;Martin, NG;Liu, JZ;Choi, J;Makowski, M;Brown, KM;Dunning, AM;Keane, TM;López-Otín, C;Gruis, NA;Hayward, NK;Bishop, DT;Newton-Bishop, JA;Adams, DJ;,
Nat. Genet. 478-81 46 5. May 2014
,PubMed ID 24686849
[POT1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216275 | POT1 (Myc-DDK-tagged)-Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1 |
CNY 4,720.00 |
|
| RC216275L1 | Lenti ORF clone of Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1, Myc-DDK-tagged |
CNY 7,120.00 |
|
| RC216275L2 | Lenti ORF clone of Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC216275L3 | Lenti ORF clone of Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC216275L4 | Lenti ORF clone of Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG216275 | POT1 (tGFP-tagged) - Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 1 |
CNY 6,320.00 |
