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MALT1 (NM_173844) Human Untagged Clone
CAT＃: SC108434
MALT1 (untagged)-Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2
CNY 7,220.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IMD12; MLT; MLT1; PCASP1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_173844, the custom clone sequence may differ by one or more nucleotides
ATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCC CTCCGGCCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCA GGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGT TGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGA AGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTATGGAACACACTGA AGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCT GGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGGACATCCTTTTGTTCAATATCAGTGGTTCAAAATGA ATAAAGAGATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAGATGCAGGCTT TTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTGGTCACAGCTGGATGTTTGCGAC ATCCCAGAGAGCTTCCAGAGAAGTGTTGATGGCGTCTCTGAATCCAAGTTGCAAATCTGTGTTGAACCAA CTTCCCAAAAGCTGATGCCAGGCAGCACATTGGTTTTACAGTGTGTTGCTGTTGGAAGCCCTATTCCTCA CTACCAGTGGTTCAAAAATGAATTACCATTAACACATGAGACCAAAAAGCTATACATGGTGCCTTATGTG GATTTGGAACACCAAGGAACCTACTGGTGTCATGTATATAATGATCGAGACAGTCAAGATAGCAAGAAGG TAGAAATCATCATAGATGAATTAAATAATCTTGGTCATCCTGATAATAAAGAGCAAACAACTGACCAGCC TTTGGCGAAGGACAAGGTTGCCCTTTTGATAGGAAATATGAATTACCGGGAGCACCCCAAGCTCAAAGCT CCTTTGGTGGATGTGTACGAATTGACTAACTTACTGAGACAGCTGGACTTCAAAGTGGTTTCACTGTTGG ATCTTACTGAATATGAGATGCGTAATGCTGTGGATGAGTTTTTACTCCTTTTAGACAAGGGAGTATATGG GTTATTATATTATGCAGGACATGGTTATGAAAATTTTGGGAACAGCTTCATGGTCCCCGTTGATGCTCCA AATCCATATAGGTCTGAAAATTGTCTGTGTGTACAAAATATACTGAAATTGATGCAAGAAAAAGAAACTG GACTTAATGTGTTCTTATTGGATATGTGTAGGAAAAGAAATGACTACGATGATACCATTCCAATCTTGGA TGCACTAAAAGTCACCGCCAATATTGTGTTTGGATATGCCACGTGTCAAGGAGCAGAAGCTTTTGAAATC CAGCATTCTGGATTGGCAAATGGAATCTTTATGAAATTTTTAAAAGACAGATTATTAGAAGATAAGAAAA TCACTGTGTTACTGGATGAAGTTGCAGAAGATATGGGTAAGTGTCACCTTACCAAAGGCAAACAGGCTCT AGAGATTCGAAGTAGTTTATCTGAGAAGAGAGCACTTACTGATCCAATACAGGGAACAGAATATTCTGCT GAATCTCTTGTGCGGAATCTACAGTGGGCCAAGGCTCATGAACTTCCAGAAAGTATGTGTCTTAAGTTTG ACTGTGGTGTTCAGATTCAATTAGGATTTGCAGCTGAGTTTTCCAATGTCATGATCATCTATACAAGTAT AGTTTACAAACCACCGGAGATAATAATGTGTGATGCCTACGTTACTGATTTTCCACTTGATCTAGATATT GATCCAAAAGATGCAAATAAAGGCACACCTGAAGAAACTGGCAGCTACTTGGTATCAAAGGATCTTCCCA AGCATTGCCTCTATACCAGACTCAGTTCACTGCAAAAATTAAAGGAACATCTAGTCTTCACAGTATGTTT ATCATATCAGTACTCAGGATTGGAAGATACTGTAGAGGACAAGCAGGAAGTGAATGTTGGGAAACCTCTC ATTGCTAAATTAGACATGCATCGAGGTTTGGGAAGGAAGACTTGCTTTCAAACTTGTCTTATGTCTAATG GTCCTTACCAGAGTTCTGCAGCCACCTCAGGAGGAGCAGGGCATTATCACTCATTGCAAGACCCATTCCA TGGTGTTTACCATTCACATCCTGGTAATCCAAGTAATGTTACACCAGCAGATAGCTGTCATTGCAGCCGG ACTCCAGATGCATTTATTTCAAGTTTCGCTCACCATGCTTCATGTCATTTTAGTAGAAGTAATGTGCCAG TAGAGACAACTGATGAAATACCATTTAGTTTCTCTGACAGGCTCAGAATTTCTGAAAAATGA >OriGene 5' read for NM_173844 unedited
CGGCCGGCGAATTCGCACGAGGCAGCAGGCCAGGCTCCCCTCGGCAAACCTGTCTAATTG GGGCGGGGAGCGGAGCTTCCTCCTCTGAGGGCCGTGCCGCGCTGCCAGATTTGTTCTTCC GCCCCTGCCTCCGCGGCTCGGAGGCGAGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACG GGGCGGGCGGGAGCCCCGGCAGTCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTGGGGG ACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCCCTCCGG CCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGG ATCAGGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGC GCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAG GAAGCCCCAGCCTGTGTCTGCTGAAGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAAT TGAGTGATTTCCTGCAGGCTATGGAACACACTGAAGTTCTTCAGCTTCTCAGCCCCCCAG GAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTTTGTGAAAC TGTGTTGCCGGGCAACTGGACATCCTTTTGTTCATATCAGTGGTTCAAAATGAATAAAGA GATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAAGATGCAG CTNTTATGTCTGTCGAGTTAATAACAATNTCACCTTTGAATTCAGCCAGTGGTCACG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_173844 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_173844.1, NP_776216.1 |
| RefSeq Size | 4996 bp |
| RefSeq ORF | 2442 bp |
| Locus ID | 10892 |
| UniProt ID | Q9UDY8 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | B cell receptor signaling pathway, T cell receptor signaling pathway |
| Gene Summary | This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018] Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (b) lacks an internal segment, compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells
,Wu, CH;Yang, YH;Chen, MR;Tsai, CH;Cheng, AL;Doong, SL;,
PLoS ONE
,PubMed ID 29953499
[MALT1]
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Other Versions
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| RC204322L1 | Lenti ORF clone of Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, Myc-DDK-tagged |
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| RC204322L2 | Lenti ORF clone of Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, mGFP tagged |
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| RC204322L3 | Lenti ORF clone of Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, Myc-DDK-tagged |
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| RC204322L4 | Lenti ORF clone of Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2, mGFP tagged |
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| RG204322 | MALT1 (tGFP-tagged) - Human mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1), transcript variant 2 |
CNY 7,552.00 |
