Nrxn1 (NM_021767) Rat Untagged Clone

Specifications

Product Data
Type	Rat Untagged Clone
Tag	Tag Free
Synonyms	Nrxn1b
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >RN208761 representing NM_021767 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGACGGCGCTGGTCCAGCATGGGGGCTGCTGTCTCCTCTGCCTGTCGCTGCTGCTGTTGGGCTGCT GGGCAGAGCTGGGCAGTGGGCTGGAGTTCCCAGGCGCTGAGGGCCAGTGGACGCGCTTCCCCAAGTGGAA CGCGTGCTGCGAGAGTGAGATGAGCTTCCAGCTGAAGACACGCAGCGCCCGCGGCCTCGTGCTCTACTTC GACGACGAGGGCTTCTGCGACTTCCTCGAGCTCATCCTGACACGCGGCGGCCGCTTGCAGCTCAGCTTCT CCATCTTCTGCGCCGAGCCCGCCACGCTGTTGGCCGACACGCCAGTCAACGACGGCGCCTGGCACAGCGT GCGCATCCGCCGCCAGTTCCGCAACACCACTCTCTACATCGACCGCGCTGAGGCCAAGTGGGTGGAGGTC AAGTCCAAGCGCAGGGACATGACGGTGTTCAGTGGGCTGTTCGTGGGCGGCCTGCCGCCTGAACTGCGAG CCGCTGCGCTCAAGCTCACCCTGGCCTCGGTGCGTGAGCGGGAGCCCTTCAAGGGCTGGATCCGTGATGT CAGGGTCAACTCGTCCCAGGCGCTGCCGGTGGACGGCAGCGAGGTCAAGCTGGACGAAGAGCCGCCCAAT AGCGGGGGCGGGAGCCCGTGCGAGGCGGGCGATGAGGGCGACGGCGGCGTGTGCCTCAACGGGGGCGTGT GCTCCGTGGTCGACGACCAGGCCGTGTGTGACTGCTCGAGGACCGGTTTCCGTGGCAAAGACTGCAGCCA AGAAGACAACAATGTAGAAGGTCTGGCGCACCTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAA GAGTATATTGCCACATTCAAGGGATCTGAGTACTTCTGCTACGACTTATCCCAAAACCCCATTCAAAGCA GCAGCGACGAAATAACTCTGTCCTTTAAAACTCTTCAGAGGAATGGACTGATGCTTCACACAGGGAAATC GGCTGATTATGTCAACCTTGCCTTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCC TTTGAAGCGCTAGTAGAGCCCGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCA GGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTGACAATATCAGTGGATGGGATTCTTACCAC AACGGGCTACACGCAAGAAGATTACACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGCCCC AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTCGTATATA AAAATAATGATGTAAGACTGGAGTTATCGCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATCCATGG TGTGGTGGCTTTTAAGTGTGAAAATGTGGCAACCTTAGACCCAATCACTTTTGAGACCCCAGAATCTTTC ATTTCTTTGCCTAAGTGGAATGCAAAGAAAACAGGCTCAATATCATTTGATTTCCGTACAACGGAGCCAA ATGGCCTCATCTTGTTTAGCCATGGCAAGCCAAGACATCAGAAGGATGCCAAGCACCCGCAGATGATTAA GGTTGACTTTTTTGCTATTGAAATGCTGGATGGCCACTTGTACCTCCTCTTAGACATGGGATCAGGTACT ATAAAAATCAAAGCCCTTCAGAAGAAAGTCAATGATGGAGAATGGTATCACGTGGATTTCCAGCGAGATG GACGGTCAGGTACCATTTCTGTCAACACACTTCGTACTCCCTACACAGCTCCCGGTGAGAGTGAGATCCT AGACCTCGATGATGAGTTGTATCTGGGTGGCTTGCCAGAAAATAAGGCTGGCCTGGTCTTCCCCACTGAG GTGTGGACTGCTCTGCTCAACTATGGCTACGTAGGCTGCATCCGGGATCTATTCATTGATGGCCAGAGCA AAGATATCCGGCAGATGGCGGAAATTCAGAGTACTGCTGGAGTGAAGCCATCCTGCTCAAGGGAGACTGC AAAACCATGCCTTAGCAATCCTTGCAAAAACAATGGCATGTGCAGGGATGGCTGGAACAGATACGTCTGT GATTGCTCTGGAACAGGCTATCTCGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTACGATGGGA GTATGTTTATGAAAATTCAGCTCCCTGTGGTGATGCACACTGAGGCCGAGGACGTTTCCTTACGGTTCAG ATCCCAGCGTGCGTACGGCATTCTGATGGCGACCACTTCTAGAGACTCCGCAGATACCCTTCGACTGGAG CTAGATGCAGGGCGCGTGAAACTCACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAG GTCCTGAGACCCTTTTTGCCGGCTATAACCTCAATGATAATGAATGGCACACAGTACGTGTGGTTCGGCG AGGAAAAAGTTTAAAGCTAACCGTGGATGATCAACAAGCCATGACAGGCCAAATGGCAGGTGATCATACA AGGCTGGAGTTTCATAACATAGAGACAGGCATCATCACAGAACGACGCTATCTTTCTTCTGTCCCCTCCA ACTTCATTGGGCACCTGCAAAGCCTCACATTTAATGGAATGGCATACATTGACTTGTGCAAAAATGGTGA TATAGATTATTGTGAACTCAATGCCAGGTTTGGATTCAGGAACATCATCGCGGATCCTGTCACCTTCAAG ACCAAATCAAGCTATGTTGCCTTAGCTACATTGCAAGCCTACACTTCTATGCATCTATTTTTCCAATTCA AGACAACATCCCTAGATGGACTAATTCTGTATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATT AGTTAAAGGGTACTTACATTATGTGTTTGACTTGGGAAATGGTGCTAACCTCATCAAAGGGAGCTCAAAC AAACCACTCAACGACAATCAGTGGCACAATGTGATGATTTCAAGGGACACCAGCAATCTCCACACAGTAA AGATCGACACAAAAATCACAACACAAATCACTGCGGGAGCCAGAAACTTAGACCTCAAGAGTGACTTGTA TATTGGAGGAGTGGCTAAAGAAACATACAAATCGTTGCCGAAACTGGTCCATGCTAAAGAAGGCTTTCAA GGTTGCCTGGCATCTGTGGACTTGAATGGCAGGCTTCCAGACCTCATATCTGATGCTCTTTTCTGCAATG GGCAAATTGAGAGAGGATGCGAAGGGCCCAGCACAACCTGTCAAGAGGACTCATGTTCAAATCAAGGCGT GTGCTTGCAGCAATGGGATGGCTTTAGCTGTGACTGTAGCATGACTTCCTTCAGTGGCCCGCTCTGCAAT GACCCTGGGACGACGTATATCTTTAGCAAAGGTGGTGGACAAATTACACATAAGTGGCCTCCTAATGACC GACCCAGTACACGAGCAGACAGGCTGGCCATCGGGTTTAGCACTGTTCAGAAGGAAGCAGTGTTGGTGCG TGTGGACAGTTCCTCAGGCCTGGGTGACTACCTTGAGCTGCACATACACCAAGGAAAAATTGGAGTTAAA TTTAATGTTGGGACAGATGACATCGCCATTGAGGAGTCCAATGCAATCATTAATGATGGAAAATACCATG TAGTGCGTTTCACGAGGAGTGGTGGCAATGCCACGTTACAGGTGGACAGCTGGCCAGTCATCGAACGATA CCCTGCAGGAAACAATGATAACGAGCGCCTGGCGATTGCTAGACAGCGAATTCCATATCGACTTGGTCGA GTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAA TTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCCAGCTCTCTGGGCTTTACTACAATGGCTTGAAAGT TCTGAATATGGCGGCAGAAAACGATGCCAACATCGCCATAGTGGGAAATGTGAGGCTGGTCGGTGAAGTG CCTTCCTCTATGACAACTGAGTCGACAGCCACTGCCATGCAGTCCGAGATGTCCACCTCAATCATGGAGA CCACCACAACCCTGGCTACCAGCACAGCTCGACGAGGAAAGCCCCCCACAAAGGAGCCTATCAGCCAGAC CACGGATGATATCCTTGTGGCCTCGGCAGAGTGTCCCAGCGACGATGAGGACATTGACCCCTGTGAGCCG AGCTCAGGTGGGTTAGCCAACCCCACCCGAGTGGGCGGCCGCGAACCATACCCAGGCTCGGCAGAGGTGA TCCGGGAGTCTAGCAGTACCACTGGCATGGTGGTGGGGATTGTCGCAGCAGCAGCTCTGTGCATCCTCAT CCTCCTCTATGCCATGTACAAGTACAGAAACCGGGATGAAGGCTCATATCACGTGGATGAGAGTCGAAAC TACATCAGTAACTCAGCACAGTCCAATGGGGCTGTGGTCAAGGAGAAGCAGCCCAGCAGTGCGAAAAGCG CCAACAAAAACAAGAAGAACAAGGATAAGGAGTATTATGTCTGA AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-RsrII
ACCN	NM_021767
Insert Size	4524 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_021767.2, NP_068535.2
RefSeq Size	5609 bp
RefSeq ORF	4524 bp
Locus ID	60391
UniProt ID	Q63372
Gene Summary	This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]

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